"About Time" is a romantic comedy science fiction film that revolves around time travel where a young man tries to change his past to have a better future.
"It's certainly my intention that 'About Time' will be the last film I direct," Curtis said in a statement.
Further explaining the reason behind his decision, he said: "In a way, I'm trying to pay attention to the message of the movie - to look at your life and to think 'How can I enjoy it without stress and worry?' And I do find making movies a long and stressful process."
The 56-year-old has given some great stories like "Notting Hill", "Four Weddings and a Funeral" and "Love Actually".
"About Time", featuring Domhnall Gleeson and Rachel McAdams, will release in India Oct 11.