The 26-year-old became the country's first male winner since Fred Perry in 1936, the year the Spanish Civil War started, Jesse Owens defied Hitler at the Berlin Olympics and Gone With The Wind was published.
It was Murray's second Grand Slam title to follow his breakthrough triumph at the US Open in 2012 which followed his Olympic gold medal as well as a heartbreaking, tearful loss to Roger Federer in the Wimbledon final.
However, Sunday's title showdown, between two men who have now contested three of the last four Grand Slam finals, rarely lived up to expectations.
Both struggled in the stifling 40-degree heat and the top-seeded Serb, who had beaten Murray in the Australian Open final in January, looked jaded after his record four hour 43-minute semi-final victory over Juan Martin del Potro.
And despite leads of 4-1 in the second set and 4-2 in the third, he was out-hit by Murray who finished with 36 winners to 31, with 21 unforced errors to the Serb's 40 and having carved out 17 break points.
Inside a baking Centre Court, and watched by Victoria Beckham, Wayne Rooney as well as Hollywood stars Gerard Butler and Bradley Cooper, the first point of the match was a punishing 20 strokes.
Murray, who has played in the final of his last four majors, had break points in the first and third games, with the Scot finally pouncing on his seventh for a 2-1 lead.
Djokovic levelled at 2-2 but Murray was the more aggressive, positive man and broke to love for a 4-3 edge firing almost four times as many winners than the top-seeded Serb.
Murray saved three break points for a 5-3 lead but Djokovic was furious that umpire Mohamed Lahyani had called a ball out at 30-40 while allowing play to continue with the Scot going to deuce.