The actress, who will also play the lead role in the film, is co-producing it with production house Phantom.
"I’m thrilled to get a chance to do this so early on in my career. And I couldn’t have found a better project than 'NH10' to kick-start this new phase in my film journey," Anushka said in a statement.
The film will be directed by Navdeep Singh post his critically acclaimed debut 'Manorama Six Feet Under'.
'NH10' is an action thriller about a road trip gone wrong.
Anushka, who recently worked with Phantom for her forthcoming project 'Bombay Velvet', is looking forward to work with the production house again.
"This is my second film after 'Bombay Velvet' with Phantom, and it’s a blast working with them. It’s going to be super-exciting working together again on what promises to be an explosive film," said Anushka, who will also be seen with Aamir Khan in Rajkumar Hirani's 'Peekay'.
The 25-year-old follows in the footsteps of actor Ranbir Kapoor who will be co-producing 'Bombay Velvet'.
Being shot this winter across the northern plains around Delhi, 'NH 10' will release on September 12 next year.