The Mad Max: Fury Road star is in early talks to play the villain in the eighth installment of the hugely successful street racing series, according to a website.
If Theron signs on, the project will reunite her with filmmaker F. Gary Gray, who directed her 2003 movie, The Italian Job.
Vin and his franchise co-stars, including Dwayne Johnson, Michelle Rodriguez, Tyrese Gibson and Ludacris, are all expected to return for the follow-up to Furious 7, which currently stands as the sixth-highest film.
Production on Fast 8 is expected to begin in the northern spring, ahead of an April 2017 release.
Photos: SRK does garba, Nawazuddin takes 'shower' in bathtub
Photos: Soha Ali Khan, Evelyn Sharma, Urvashi Rautela at Mumbai airport
Spotted: Lara Dutta, Mahesh Bhupathi with their daughter in Bandra
Photos: SRK, Tamannaah Bhatia, Varun Dhawan at Mehboob Studio
Birthday special: Sushant Singh Rajput's journey from TV to films