The 40-year-old has covered the walls of his new Hollywood venue club, Bootsy Bellows, with raunchy pictures of his mother Brenda, including some risque bondage-themed shots, reported Sun Online.
"People are like, 'Dude, your mom is naked all over your club. It was the '60s and New York. Later she went on to become a marriage and family counsellor. This is a way of honouring her youth," he said.
The club is already a favourite with the likes of Katy Perry, Robert Pattinson and Lindsay Lohan, but the "Scream" actor says he is nervous about showing his eight-year-old daughter Coco the nightclub.
"I don't know what I'm going to do when I walk my daughter through there - I'll have to cover it up," he said. Arquette, who has filed for divorce from his wife Courteney Cox two years after they split, recently said he had named the club Bootsy Bellows in his mother's honour.