The 38-year-old, who was at the 2013 Beauty Inc Awards here to receive a Newcomer of the Year award for her cosmetics line Flower, announced on Wednesday that she is expecting a baby girl.
"Thank you to WWD Beauty Inc for awarding Flower Beauty. I am so proud to accept this in celebration of women, including my daughter and my future daughter," she said on receiving the award," Us Weekly quoted Barrymore as saying.
The "Charlie's Angels" star, who already has a 14-month-old daughter Olive, launched the brand in January.
Spotted: Virat Kohli, Anushka Sharma and other celebs at Mumbai airport
Photos: Salman Khan's 'special friend' Iulia Vantur at a song launch
Photos: Hrithik Roshan, Anushka Sharma, other celebs dazzle at event
In Pictures: Sex scandals involving Indian politicians
Photos: Abhishek Bachchan and Farah Khan at Boman Irani's birthday bash