It features Farhan Akhtar and Vidya Balan in lead roles.
Ekta Kapoor of Balaji Motion Pictures is confident the movie will be a "laughathon and entertainment all the way".
"It's going to be exciting working with Farhan, who is extremely talented and of course Vidya Balan, who is an actress par excellence and my personal favourite," said Kapoor.
The actors are joined by an ensemble cast of stand-up comedian Vir Das, actor Ram Kapoor and his wife Gautami, singer-actress Ila Arun and legendary singer Hariharan, who plays Farhan's father in the film.
The story of the sequel focusses on iconic characters, Sid and Trisha, played by Rahul Bose and Mallika Sherawat respectively, in the sequel. Sid and Trisha will now be seen as husband and wife.
Now they must address themselves to the impossible task of coping with each other's fantasies and realities.
Vidya and Farah make the perfect Sid and Trisha, according to producer Pritish Nandy.
"'Shaadi Ke Side Effects' is a witty, sexy, hilarious comedy that will warm your hearts and to all you newly-weds, it's time to pick a side again in the war of Mars versus Venus," he said in a statement.
The romantic comedy will go on the floors Feb 17, and will hit theatres Dec 6.