Paris: Novak Djokovic and Rafael Nadal will clash in a French Open quarter-final blockbuster in one of the sport's most-eagerly awaited clashes of recent times.

World number one and top seed Djokovic eased into the last eight on Monday with a 6-1, 6-2, 6-3 win over France's Richard Gasquet.

Defending champion Nadal, seeking a 10th Roland Garros crown, saw off unseeded American Jack Sock, 6-3, 6-1, 5-7, 6-2. It was Nadal's 70th career win at the French Open against just one defeat and his 39th in a row at the tournament he has dominated for a decade.

Novak Djokovic and Rafael Nadal
Novak Djokovic (left) and Rafael Nadal celebrate after defeating their opponents in the French Open at the roland Garros on Monday. Pic/AFP 

"It's the biggest challenge I can have on clay," said Djokovic who needs a French Open title to complete the career Grand Slam."He's lost just once here in his career."

On facing Djokovic, sixth-seed Nadal said: "I will have to play my best tennis. "He's the world number one and is having a great season. It'll be a complicated match."

Nadal has beaten Djokovic in the 2012 and 2014 finals in Paris as well as the 2013 semi-finals and holds a career 23-20 edge in head-to-head meetings.