The actor tweeted, You are the only reason behind the biggest opening weekend of my career! Love Rowdy.
The film, directed by Prabhu Deva, is Akshay's widest release so far - it opened on 2,800 screens in the country.
Made on a budget of Rs.45 crore, the film released Friday and earned Rs.29.8 crore on the first two days.
Co-produced by Sanjay Leela Bhansali and Ronnie Screwvala, the film marked Akshay's return to a full-fledged action role after seven years.