Aniston, 43, who has been staying out of the spotlight lately, accepted the award from "Ted" stars Mila Kunis and Mark Wahlberg.

Jennifer Aniston. Pic/Santa Banta

"I would like to say thank you to the television show 'Friends' for letting me unleash my inner-sweetheart, and here's to Seth Gordon (Horrible Bosses' director) for letting me be a dirtbag," she said.

Also nominated in the category were Bryce Dallas Howard for "The Help", Colin Farrell for "Horrible Bosses", Jon Hamm for "Bridesmaids" and Oliver Cooper for "Project X".