Aniston, 43, who has been staying out of the spotlight lately, accepted the award from "Ted" stars Mila Kunis and Mark Wahlberg.
"I would like to say thank you to the television show 'Friends' for letting me unleash my inner-sweetheart, and here's to Seth Gordon (Horrible Bosses' director) for letting me be a dirtbag," she said.
Also nominated in the category were Bryce Dallas Howard for "The Help", Colin Farrell for "Horrible Bosses", Jon Hamm for "Bridesmaids" and Oliver Cooper for "Project X".
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