The "Pirates of the Caribbean" star, 48, grabbed his guitar and joined Manson on stage Wednesday night for a rollicking performance at the Golden Gods Awards concert at Club Nokia in Los Angeles, reported People magazine.
In true Depp style, he played it cool keeping his head low, almost to the point of being incognito. With an ivory guitar slung low on his thigh, Depp wore a black button-down shirt with the sleeves rolled up, black boots, black jeans and a black cowboy hat with a white feather pulled down, covering most of his face.
After running through the song "Sweet Dreams," Manson, 43, shouted to the crowd, "If you don't recognize my personal friend... my personal savior, my personal guitar hero... Johnny Depp!" The crowd roared its approval.
Next they moved on to Manson's "The Beautiful People." All the while Depp was straight faced, focusing on his playing, though he broke into an occasional smile absolutely in control, bemused at times, but obviously enjoying himself.
The actor has been hanging out with rock stars lately. Back in February he chilled out with Paul McCartney and Bruce Springsteen at the Foo Fighters' after-Grammys party.