Holmes, plays a depressive poet who gets pregnant by a rapper of similar nature, played by Kirby, reports thesun.co.uk.
She was reportedly seen getting too close with Kirby and was making funny faces in between the takes. Holmes and Kirby were also seen holding hands and kissing as they filmed a scene outside a church in New York.
"Mania Days" is being shot just a few blocks from where Holmes used to live with ex-husband Tom Cruise. The film, produced by Spike Lee is set to release in 2014.