The 29-year-old posted a video, in which she is shown getting a boombox tattoo erased via laser treatment on microblogging website Twitter, reports femalefirst.co.uk.
This is one of the 15 tattoos she has.
"Not looking forward to this afternoon ... I'm getting my first tattoo removal! It's going to burn like the snap of 1,000 rubber bands!" she tweeted.
"I did the crime I am now doing the time! No pain no gain! (sic)" she added.
Osbourne's fans responded positively to her post, praising her for making the decision.
In 2010, Osbourne revealed that she was going to get rid of most of her body art when she had the time because she now feels many of the tattoos were a "mistake".