The 42-year-old hit the headlines in April after she checked into a mental health facility in Connecticut, where she spent five days combating a serious bout of depression.
"As hard as it is, it puts everything into perspective on a personal and professional level. I'm not so consumed about what people think or say like I used to be. It's made me much more centered and I'm not afraid to say no and if people don't like that, well, tough.
I'm looking out for myself more. "We spend a lot of time in our business being nice and giving a lot out to complete strangers. And then you turn around and go, 'Wait a minute, I'm exhausted by this.
It's our time now and we should be enjoying every minute'," she said. Zeta-Jones' treatment came less than a year after husband Michael Douglas was diagnosed with throat cancer.