Manaudou, the younger brother of former Olympic women's 400m freestyle champion Laure, hit the wall in 21.34secs to win the one-lap dash.
Cullen Jones of US won the silver in 21.54sec, with Brazil’s Cesar Cielo taking bronze.
Mumbai Roundup: 9 incidents that took place this week
Photos: Ajay Devgn, Parineeti, Tabu at 'Golmaal Again' trailer launch
Photos: Dipika Pallikal Karthik oozes oomph in bikinis and sarees
Photos: Kareena Kapoor Khan's grand birthday bash
Photos: 'Dangal' girls Sanya Malhotra, Fatima Sana Shaikh's dinner outing