Located at New Customs House in South Mumbai, the post office was inaugurated by Post Secretary and Postal Services Board Chairperson P Gopinath.
As of now, 12 female employees will run the Mahila Dak Ghar, headed by a Senior Superintendent of Posts, an official statement said on Friday.
The post office will offer both traditional and modern postal services like booking of registered and speed post articles, e-Money Order, Western Union Money Transfer, e-payment of utility bills of MTNL, BEST and Mahanagar Gas Ltd, besides the Post Office Savings Bank transactions.
Currently, the Maharashtra Postal Circle has a total staff strength of 26,468, out of which 5,008 are women.
"As a mark of respect to the women of Maharashtra, we decided to launch the first Mahila Dak Ghar in this circle in Mumbai," Chief Post Master General (Maharashtra and Goa Circle) K C Mishra said.
Earlier this year, on the occasion of the International Women's Day on March 8, Minister for Communication and IT Kapil Sibal had inaugurated country's first all-women post office in New Delhi. He had said more such offices would be opened in the country, especially in the metro cities.
Besides, India Post on Friday also released a commemorative postage stamp to mark the centenary of Mumbai GPO building.
The GPO was established in 1794 by the then Postmaster General for Bombay Presidency, Charles Elphinstone.