The 43-year-old plays real-life AIDS victim Ron Woodroof in the drama, which is expected to release later this year.
"There's nothing out there that I am chasing. I want my work to translate. Last year was an incredibly creative year of work for me... I'm looking for great experiences," USAToday.com quoted McConaughey as saying.
Directed by Jean-Marc Vallee "Dallas Buyers Club" required McConaughey to loose a lot of weight. The actor lost almost 21 kgs to fit into the perfect frame.