The 23rd film in the secret agent series also picked up the blockbuster of the year trophy - selected from the top 10 UK box office hits of 2012, reported BBC News.
Toby Jones was named best actor for 'Berberian Sound Studio', while Andrea Riseborough was named best actress for 'Shadow Dancer'.
The awards, at the London Film Museum, were presented by Stephen Mangan. 'Skyfall' has also been nominated for outstanding British film at this year's Baftas, which take place in London next weekend.
Evening Standard editor Sarah Sands said, "Thanks in part to the extraordinary success of Skyfall - a truly big British movie, delivered with a panache Hollywood could envy - 2012 also highlighted the creativity, vision and talent of a new generation of British film-makers, actors and actresses."
Photos: Salman Khan returns from Jodhpur to Mumbai
Pics: Sidharth Shukla-Rashami Desai's sizzling chemistry at TV show launch
Ooh La Lana! WWE Diva flaunts sexy curves in these 30 pictures
15 'peach' perfect photos of Priyanka Chopra at People's Choice Awards 2017
62 going on 16: These photos of Rekha prove she is 'forever young'