Another way to diagnose head, neck cancer

Updated: Jun 28, 2018, 10:58 IST | ANI

The researchers, who tested mechanical properties of OSCC cells, found them to be 'softer' than benign cells

Another way to diagnose head, neck cancer
Representational picture

Washington D.C.: It is quite common that head and neck cancers are often diagnosed late. However, with the new research conducted in Germany, it is now possible to detect and diagnose the oral squamous cell carcinomas (OSCCs), most common head and neck cancers, at an earlier stage.

The researchers, who tested mechanical properties of OSCC cells, found them to be 'softer' than benign cells. Lead authors Josef Käs and Torsten W. Remmerbach said, "Early diagnosis and treatment of OSCCs is essential to enabling recovery. But in up to 60 percent of cases, the diagnosis is late because the growth has not been recognised, or has been mistaken as harmless."

The research team examined if cells' mechanical properties could be used as a marker for malignancy. As well as being softer than benign cells, the team saw that cancer cells exhibited a faster contraction than their benign counterparts when testing the relaxation behaviour after stress release.

Remmerbach added, "This new way of drawing distinction between malignant and benign cells could enable an early confirmation of cancer diagnoses, by testing cell samples of suspect oral lesions."

The researchers used an optical stretcher to analyse the properties of the cells. Their experiments revealed that cells of primary OSCCs were deformed by 2.9 percent, rendering them softer than cells of the healthy mucosa, which were deformed only by 1.9 percent.

Co-author Jörg Schnauß said, "What we found also has implications for the way studies in cancer research are carried out. Many studies are performed with cancer cell lines rather than primary cells. When comparing the mechanical properties of both, our results showed that longtime culturing leads to softening of cells.

"This softening in the culturing process could potentially affect the significance of test results. Because of that, we suggest that future research uses primary cells to ensure accuracy."

The study appears in the journal Convergent Science Physical Oncology.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/ reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

DISCLAIMER: mid-day and its affiliates shall have no liability for any views, thoughts and comments expressed on this article.

Shocking! Leopard spotted at Korum Mall in Thane

This website uses cookie or similar technologies, to enhance your browsing experience and provide personalised recommendations. By continuing to use our website, you agree to our Privacy Policy and Cookie Policy. OK