Andy Murray's reign as Queen's champion came to an abrupt end as the world number four suffered a shock 6-3, 6-7 (4/7), 7-6 (7/1) defeat to France's Nicolas Mahut, while four-time winner Andy Roddick fared no better as France's Edouard Roger-Vasselin clinched a shock 6-4, 4-6, 7-5 victory over the seventh seed
Top seed Murray had won the pre-Wimbledon grass-court event in west London twice in the last three years.
Roddick has slipped out of the top 30 in the world rankings after an injury-ravaged campaign, but losing to Roger-Vasselin, ranked 67th, on the grass he regards as his favourite surface is a new low for the American.
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