Can aspirin reduce Alzheimer's disease symptoms?

Administering lowdose aspirin a commonly used medication to treat pain fever or inflammation may help in reducing plaques in the brain reducing Alzheimers disease pathology as well as protecting memory reveals a study led by Indianorigin researcherThe findings showed that the common overthecounter medication decreases amyloid plaque major signs of Alzheimers disease pathology in mice by stimulating lysosomes the component of animal cells that help clear cellular debrisThe study identifies a possible new role for one of the most widely used common overthecounter medications in the world said senior author and lead research investigator Kalipada Pahan from Department of Neurological Sciences Rush Medical CollegeThe research adds another potential benefit to aspirins already established uses for pain relief and for the treatment of cardiovascular diseases Pahan saidIn the study published in Journal of Neuroscience the team gave aspirin orally for a month to genetically modified mice with Alzheimers pathology then evaluated the amount of amyloid plaque in the parts of the brain affected most by Alzheimers diseaseThe results showed that the aspirin medications augmented TFEB a protein considered as the master regulator of waste removal stimulated lysosomes and decreased amyloid plaque pathology in the miceUnderstanding how plaques are cleared is important to developing effective drugs that stop the progression of Alzheimers disease Pahan explainedHowever experts have questioned the potential of aspirin citing the failure of several major recent human trials into drugs that reduce amyloid plaquesA number of compounds have achieved this level of amyloid reduction in mice yet have subsequently failed in clinical trials in humans Clive Ballard from the University of Exeter was quoted as saying to the newatlascomThe failures may be as a result of the differences between Alzheimer mice and human pathology and the poor translation of benefits into humans he saidMoreover in human clinical trials the drug was found to have no beneficial effects on outcome measures and was associated with an increased risk of gastrointestinal haemorrhage noted Rob Howard from the University College LondonCatch up on all the latest Crime National International and Hatke news here Also download the new midday Android and iOS apps to get latest updatesThis story has been sourced from a third party syndicated feed agencies Except for the change in headline the story has been provided ASIS AS AVAILABLE without any verification or editing from our side Midday accepts no responsibility or liability for its dependability trustworthiness reliability and data of the text Midday managementmiddaycom reserves the sole right to alter delete or remove without notice the content in its absolute discretion for any reason whatsoever