An analysis of MRI scans shows that a lower accumulation of abdominal fat in midlife is associated with a significant slowing of brain atrophy (shrinkage), preservation of key brain structures, and better cognitive performance in late midlife -- independent of weight loss.

Magnetic resonance imaging (MRI) scans of the brain and abdomen were analysed of 533 women and men in late midlife, who were followed for up to 16 years. During this period, participants underwent repeated MRI measurements of visceral fat and brain structures, along with their cognitive assessment.