Turns out, stressful situations affect the brain and body differently in people with schizophrenia as compared to people without the mental illness. A new CAMH study showed the relationship between two chemicals released when people experienced stress - one released in the brain and the other in saliva - differs in people with schizophrenia. Postdoctoral Research Fellow, Dr. Christin Schifani, said, "We found a disrupted stress response in people with schizophrenia, which did not occur in either healthy individuals or people at clinical high risk for developing psychosis."

As most people with schizophrenia experience psychosis, identifying differences between people at high risk for psychosis and those with schizophrenia may shed light on how schizophrenia develops and ways to prevent its onset. "The fact we see this disrupted stress response in people with schizophrenia, but not in people at high risk for psychosis, suggests an opportunity to intervene to prevent schizophrenia," said Dr. Romina Mizrahi, Clinician Scientist. In the study, the new insights come from examining two important chemical messengers - dopamine and cortisol - in people under stress. Dopamine is a neurotransmitter, a chemical that carries signals from one brain cell, or neuron, to another.