As per the data released by the Zero Fatality Corridor project, a joint initiative of Maharashtra State Road Development Corporation (MSRDC), Maharashtra Highway Police, Mahindra and Mahindra, and SaveLIFE Foundation, to reduce deaths on the Mumbai-Pune Expressway, the number of fatalities on MPEW have now seen an overall reduction of 43 percent since the project began in 2016.

The MPEW suffered 151 deaths in 2016 and 86 in 2019. The severity of crashes, which is defined as the number of deaths per hundred crashes, has also come down from 53.5 percent to 24.8 percent.