Separate Iranian strikes hit a high-rise apartment building in Tel Aviv and other sites in central Israel. A hospital in Tel Aviv said it had received 16 wounded people, three with serious injuries

Israel, meanwhile, carried out strikes on Iran's Arak heavy water reactor, its latest attack on Iran's sprawling nuclear program, on the seventh day of a conflict that began with a surprise wave of Israeli airstrikes targeting military sites

Iran has fired hundreds of missiles and drones at Israel, though most have been shot down by Israel's multi-tiered air defences, which detect incoming fire and shoot down missiles heading toward population centres and critical infrastructure

The missile hit the Soroka Medical Centre, which has over 1,000 beds and provides services to the approximately 1 million residents of Israel's south

The strikes came a day after Iran's supreme leader rejected US calls for surrender and warned that any military involvement by the Americans would cause irreparable damage to them

A Washington-based Iranian human rights group said at least 639 people, including 263 civilians, have been killed in Iran and more than 1,300 wounded. In retaliation, Iran has fired some 400 missiles and hundreds of drones, killing at least 24 people in Israel