Chelsea Handler, a close friend of Jennifer Aniston, verbally slaughtered Angelina Jolie during a recent stand-up comedy show in New Jersey.

The comedienne threw a handful of foul-mouth words at the actress, calling her a 'homewrecker' among a few other jabs, reports the CBS News.

"She can rescue as many babies from as many countries as she wants to," the 35-year-old said of Jolie, who has three adopted children.

"I don''t f--king believe you...she gives interviews, 'I don''t have a lot of female friends'. Cause you''re a f*****g c**t that''s why. You''re a f*****g b***h," she added.

And this is not the first time Handler has slammed Jolie.

Before introducing Aniston as a guest on her E! talk show in August, Handler called Jolie 'evil' and even mocked her 9-year-old son, Maddox.

She and Aniston were recently spotted vacationing together with other guests in Los Cabos, Mexico, over Thanksgiving weekend.