Set during Christmas time, Godmothered is a comedy about Eleanor, a young, inexperienced fairy godmother-in-training (Jillian Bell), who upon hearing that her chosen profession is facing extinction, decides to show the world that people still need fairy godmothers.

Finding a mislaid letter from a 10-year-old girl in distress, Eleanor tracks her down and discovers that the girl, Mackenzie, is now a 40-year-old single mom (Isla Fisher) working at a news station in Boston. Having lost her husband several years earlier, Mackenzie has all but given up on the idea of a "happily ever after", but Eleanor is determined to give Mackenzie a happiness makeover, whether she likes it or not.