Italian scientists have created a nasal spray using gold nanoparticles to deliver lithium directly to the brain. This method may offer safer treatment for bipolar disorder, Alzheimer’s, and viral brain infections by reducing side effects on kidneys and thyroid
The approach could open safer treatment possibilities
Italian researchers have developed a nasal spray using gold nanoparticles to deliver lithium directly to the brain. The approach could open safer treatment possibilities for bipolar disorder, Alzheimer’s disease, and viral brain infections.
Lithium has been one of the most reliable treatments for bipolar disorder for decades. But when taken orally, it can cause side effects, especially on the kidneys and thyroid. Their research shows that gold nanoparticles can transport lithium across the nasal passage directly into the brain.
The nanoparticles are coated with lithium and functionalised with glutathione, a molecule that helps them enter cells and release lithium where it is needed. Once inside cells, the nanoparticles break down, releasing lithium in effective doses without exposing the rest of the body to unnecessary risk.
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