<p>While stress is known to significantly contribute to the onset of various health issues, a new study on Sunday showed how stress can worsen colorectal cancer (CRC).&nbsp;</p>
<p>A team of Chinese researchers showed that chronic stress disrupts the balance of gut microbiota, which then hastens the progression of CRC.</p>
<p>By eliminating some gut bacteria and inducing stress, they found a particular bacterial species as a potential therapeutic target.</p>
<p>The team from West China Hospital, Sichuan University of China, used an antibiotic cocktail -- vancomycin, ampicillin, neomycin, and metronidazole -- to eradicate gut microbiota. It was followed by faecal microbiota transplantation to find whether gut microbiota was necessary for chronic stress to fasten the progression of colorectal cancer.</p>
<p>The results showed that while chronic stress increased tumour growth, it also decreased beneficial gut bacteria, particularly the Lactobacillus genus, -- essential for a healthy immune response against cancer.</p>
<p>&ldquo;Stress-related CRC progression can be attributed to a reduction in beneficial gut bacteria, as this weakens the body&rsquo;s immune response against cancer,&rdquo; said lead researcher Dr Qing Li from the varsity.</p>
<p>Lactobacillus -- being sensitive to vancomycin and ampicillin -- was found depleted in both the control and stress groups by the antibiotic cocktail.</p>
<p>To further explore how Lactobacillus influences CD8+ T cell levels -- which play a crucial role in the body's anti-tumour immunity -- and CRC progression the researchers supplemented mice with Lactobacillus during chronic stress and observed reduced tumour formation.</p>
<p>&ldquo;Through faecal analysis, we found that Lactobacillus plantarum (L. plantarum) specifically regulated bile acid metabolism and enhanced the function of CD8+ T cells. This indicates how Lactobacillus may enhance anti-tumour immunity,&rdquo; Li said.</p>
<p>The research showed potential for Lactobacillus-based therapies in treating patients, particularly those affected by chronic stress.</p>
<p>&ldquo;Restoring beneficial bacteria in the gut, such as Lactobacillus, could strengthen the body&rsquo;s natural defences against colorectal cancer,&rdquo; concluded Li.</p>
<p>The study was presented at the United European Gastroenterology Week 2024 in Vienna, Austria.</p>
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By eliminating some gut bacteria and inducing stress, they found a particular bacterial species as a potential therapeutic target

Study shows how stress worsens colorectal cancer

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A team of Chinese researchers showed that chronic stress disrupts the balance of gut microbiota, which then hastens the progression of colorectal cancer

Study shows how stress worsens colorectal cancer

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Study shows how stress worsens colorectal cancer

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