Super-resolution microscopy requires hundreds of frames, causing motion blur when capturing fast-moving living cells. A new imaging technique called Spatial Polarisation-Induced Fluorescence Fluctuation Imaging (SPIFFI) overcomes this limitation by leveraging light polarisation during a single camera exposure. This allows scientists to capture fine structures and produce true super-resolution videos of live cellular dynamics in real time, significantly advancing research in biology, neuroscience, modern drug discovery, biomedical, and clinical sciences.

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