Nadal, the second-seeded 2010 champion who watched the 2012 US Open from his home in Spain as he endured a seven-month injury layoff, cruised to a 6-4, 6-2, 6-2 win over America's Ryan Harrison to record a 16th win on hard courts this year.

The 27-year-old Spaniard has captured nine trophies since his return from injury in February, building up a 54-3 record in the process, and came into New York having won back-to-back Masters titles at Montreal and Cincinnati, comfortably erasing his shock first-round exit at Wimbledon.