The 37-year-old married Will Kopelman in June and are expecting their first child together later this year.
Barrymore says she wants to have a big family with her new husband.
"I can't wait until I have my children. I love the idea that they don't have to do something that they have no interest in, that they can do something completely opposite if they want to," femalefirstc.co.uk quoted Barrymore as saying.
"I will be so surprised if they don't want to do something involving food or wine or art, but I'll be Ok with it. I just want to build fun, great things for my family," she added.