The 48-year-old handpick some of her favourite home wear items like chair, cushions which will be showcased on Joss and Main website, reports contactmusic.com.
The sales from any of the sold items will go to Epidermolysis Bullosa Medical Research Foundation, LA, to raise awareness of the tissue disease.
"We are thrilled to present Courteney Cox's Curate for a Cause collection. Inspired by her Malibu home's signature 'organic modern' style, the Cougar Town actress brings A-list appeal to this exclusive array of furniture and accents," a message on the Joss and Main website said.
Cox later promoted the website on Twitter by pasting a link on her account.