Wilshere had been scheduled to make his return after a 17-month injury absence at the Madejski Stadium but, having unexpectedly started in the 1-0 home victory over Queens Park Rangers on Saturday, he will be rested.
Wenger said: “After a game like that, I will certainly not play him on Tuesday. Will I play him (at Manchester United) next week? I don’t know.”
Wilshere’s withdrawal will be just one of several changes made by Wenger as the manager rotates his squad. Yet despite the fact the line-up will bear only a passing resemblance to the side that faced QPR, Arsenal’s continuing seven-season trophy drought means that expectations remain high.