Wilshere had been scheduled to make his return after a 17-month injury absence at the Madejski Stadium but, having unexpectedly started in the 1-0 home victory over Queens Park Rangers on Saturday, he will be rested.
Wenger said: “After a game like that, I will certainly not play him on Tuesday. Will I play him (at Manchester United) next week? I don’t know.”
Wilshere’s withdrawal will be just one of several changes made by Wenger as the manager rotates his squad. Yet despite the fact the line-up will bear only a passing resemblance to the side that faced QPR, Arsenal’s continuing seven-season trophy drought means that expectations remain high.
Photos: Salman Khan returns from Jodhpur to Mumbai
Pics: Sidharth Shukla-Rashami Desai's sizzling chemistry at TV show launch
Ooh La Lana! WWE Diva flaunts sexy curves in these 30 pictures
15 'peach' perfect photos of Priyanka Chopra at People's Choice Awards 2017
62 going on 16: These photos of Rekha prove she is 'forever young'