The 26-year-old portrayed vampire Edward Cullen in the series and is delighted that it has come to an end, reported a website.
"It's a relief not to put the contact lenses in. It's been absolutely awful having those stupid things in my eyes. Even if they said, 'We'll give you a billion dollars to do it again,' I don't know that I'd want to," he said.
Pattinson will next be seen in 'Cosmopolis', directed by David Cronenberg, as a billionaire tycoon Eric Packer. "I saw 'Cosmopolis' and liked it. I don't normally like my stuff but I didn't really recognise myself. I was so terrified to do it at the beginning and thought everyone's going to say, 'Director David Cronenberg's sold out.' So to get it to Cannes was the coolest thing ever. Getting this movie, getting it into Cannes and getting the movie I got recently are three of the happiest moments of my life," he said.