Tottenham down Reading 3-1 in EPL
Spurs had drawn two and lost one of their three previous league matches this term under Villas-Boas.
Defoe gave Spurs an 18th minute lead at the Madejski Stadium. In the 71st minute Gareth Bale scored the second before Defoe added a third three minutes later.
Reading’s Hal Robson-Kanu scored a consolation goal in the closing moments.