Arsenal vs Barcelona
Arsene Wenger's side have again paid the price for not topping their group by drawing the holders. The Gunners have not made it past the Round of 16 for the past five years and come up against the Catalans' fearsome attacking triumvirate. In Lionel Messi, Neymar and Luis Suarez, Luis Enrique's side have the most potent strike-force on the continent. Their defence shipped just four goals in the group stage, amassing 14 points along the way.
Manchester City vs Dynamo Kiev
On paper this is by far the easiest task for the trio of EPL clubs left in the Champions League, but Sergei Rebrov will be hoping his side can upset the odds. Second in the Ukrainian league, Kiev finished runners-up to Chelsea in Group G, but a win away in Porto shows they are not to be taken lightly. Winger Andriy Yarmolenko is certainly a player who could hurt City, who are looking to get past this stage for the first time.
Chelsea vs Paris St Germain
Jose Mourinho will lead his struggling side into a game against Ligue 1's dominant outfit for a third successive year, having lost in extra-time in the Round of 16 last season. The year before, the Blues won by away goals to reach the semi-finals, but Laurent Blanc's side have only lost once all season and that was at Real Madrid. They top Ligue 1 by 17 points already.
Chelsea manager Jose Mourinho
Liverpool vs Augsburg
Markus Weinzierl's Augsburg finished fifth in the Bundesliga last term to reach continental competition for the first time and they came through despite losing their opening two games. Their main goal threat comes from Paraguay international Raul Bobadilla.
Man United vs FC Midtjylland
United's reward for dropping out of the Champions League is a tie with reigning Danish Superliga champions Midtjylland, who are based in the town of Herning. Formed in 1999, the year United won their famous treble of Premier League, Champions League and FA Cup, they beat Southampton in a qualifier in August on their way to reaching the Europa League group stage for the first time. They finished second in Group D behind Napoli and have some talented players in the likes of winger Pione Sisto and forward Morten Rasmussen.
Tottenham vs Fiorentina
Like Chelsea, Spurs will be feeling a sense of déjà vu as they face the same opponents they played at this stage of the competition last season. And, like their London rivals, Mauricio Pochettino's side came up short and were eliminated as they were beaten 0-2 in Florence. Paulo Sousa has his side up to second in Serie A, but they were beaten to top spot in Group I by Basle. Their top scorer is former Blackburn striker Nikola Kalinic.