Every year on World Haemophilia Day, celebrated on April 17, the global medical community turns its attention to a condition long characterised as a man’s disease. However, beneath this traditional narrative lies a silent, growing crisis: thousands of Indian women who carry the haemophilia gene suffer from chronic, debilitating bleeding symptoms, yet remain trapped in a cycle of misdiagnosis. While medical textbooks once labelled women as ‘passive carriers’, the data tells a far more urgent story. According to the World Federation of Hemophilia, nearly 33 per cent of people living with haemophilia globally are female, yet the Hemophilia Federation India notes a massive registration gap, with tens of thousands of women likely missing from official records. Experts now reveal that 1 in 3 women carrying the gene have clotting factor levels below 40 per cent—technically placing them in the same category as those with mild haemophilia. Beyond the carrier label, haematologists are breaking down the medical bias that dismisses heavy periods and easy bruising as normal. This dismissal leads to more than just fatigue; it creates dangerous surgical risks and a lifetime of functional anaemia. By understanding the science of the symptomatic carrier and identifying your specific bleeding phenotype, you can bridge the gap between just a heavy period and life-saving haematological care. The myth of the silent carrier The belief that women cannot have haemophilia is not just outdated, it is biologically incorrect. The explanation lies in a complex genetic process called X-chromosome inactivation. Dr Vijay Ramanan, senior consultant clinical haematologist at Ruby Hall Clinic in Pune, explains that the carrier label is often a dangerous oversimplification. "The concept of X-chromosome Lyonization explains why this label can be misleading. In every female cell, one of the two X chromosomes is randomly inactivated. If the X chromosome carrying the normal clotting gene is inactivated in a majority of cells, the defective gene becomes more functionally dominant," Dr Ramanan notes. This genetic lottery means a woman’s carrier status isn’t just a silent trait, it’s an active biological tug-of-war. “The result is a woman who, despite being a carrier, has clotting factor levels (Factor VIII or IX) low enough to produce symptoms comparable to mild or even moderate haemophilia. Many women who are labelled as ‘carriers’ may, in reality, experience active bleeding tendencies and require medical attention similar to male patients," he adds. The normal period fallacy In the Indian context, the greatest barrier to diagnosis is often cultural. Heavy menstrual bleeding is frequently normalised within families, passed off as a routine hereditary trait rather than a medical red flag. "In many Indian households, heavy menstrual bleeding is often normalised and dismissed as a routine occurrence," Dr Ramanan further explains. However, he insists there are clear clinical markers that differentiate a heavy flow from a life-altering disorder. "One of the most important indicators is the frequency of pad or tampon use—soaking through protection every hour for several consecutive hours is not considered normal." Other warning signs include:1. Menstrual bleeding lasting longer than seven days.2. Passing large clots (greater than 2–2.5 cm).3. The need for double protection to manage the flow. The gynaecology versus haematology gap When a woman seeks help for these symptoms, she often finds herself in a diagnostic loop. Because the primary symptom is menstrual, patients are almost exclusively treated by gynaecologists who may look for structural issues like fibroids or cysts, missing the underlying blood chemistry. Dr Kunal Sehgal, managing director and chief pathologist at Neuberg Sehgal Path Lab, sees this gap daily. "I often see women with persistent heavy periods undergoing multiple ultrasounds or being started on hormonal therapy without improvement. The missing link is frequently a basic haemostasis evaluation. Not all bleeding is due to a uterine problem—conditions like mild clotting factor deficiencies or platelet function issues can present only as heavy menstrual bleeding. These are not picked up on imaging," Dr Sehgal explains. To fix this, the health expert advocates for a shift in protocol. He says, "Early collaboration between gynaecologists and haematology-focused diagnostics is essential to avoid years of misdirected treatment." The double burden of functional anaemia Living with an undiagnosed bleeding disorder is a marathon of exhaustion. When a woman bleeds excessively every month, her body’s iron stores are permanently depleted, leading to a state experts call functional anaemia. "Chronic undiagnosed bleeding often leads to ongoing iron loss, creating a silent but significant energy deficit. The body adapts, but at a cost. Simply giving iron supplements provides temporary relief if the bleeding source is not addressed," says Dr Sehgal. Dr Chandrakant Lahane, consultant haematologist at Sahyadri Super Speciality Hospital, emphasises the cognitive toll of this state. "These individuals continue to suffer from what has been referred to as ‘functional anaemia,’ where they are symptomatic of the condition without proper diagnosis, which in turn affects their cognitive function and work output. The result is a woman who is technically functioning but living with constant fatigue, low stamina, and impaired physical health,” Dr Lahane explains. Hidden dangers in the operating room The most perilous moment for an undiagnosed woman often comes during routine surgery. Without a known history of a bleeding disorder, procedures like a C-section, gallbladder removal, or even a simple tooth extraction can turn into a medical emergency. "Bleeding tendencies that have not been diagnosed can really make things difficult during even minor operations. What's more worrying is that in some of the milder disorders, routine tests may still appear normal. Not recognizing the problem means a greater risk of spontaneous bleeding, slower healing, or the requirement for transfusion," warns Dr Sehgal. Dr Ramanan adds, "In some cases, bleeding may not be immediate but can occur hours or even days after the procedure, making it more dangerous and difficult to manage." The self-audit: When to seek a haematologist Because symptoms can be subtle or mucocutaneous (skin and mucus membranes) rather than the joint bleeds typically seen in men, women must perform a self-audit of their medical history. Dr Ramanan shares a checklist of symptoms that warrant a specialised haematological evaluation:1. The first period warning: If a girl's very first period (menarche) was so heavy it required hospitalisation or a transfusion.2. Subtle bleeding: Frequent nosebleeds or prolonged bleeding after minor beauty procedures like threading or waxing.3. Post-trauma: Easy bruising from minimal impact and prolonged bleeding after dental work.4. Obstetric history: Excessive bleeding after a miscarriage or postpartum haemorrhage. Navigating the lab: Beyond basic tests A major pitfall in the journey to diagnosis is the reliance on standard blood tests. Many women are told their blood work is normal because doctors only order basic screenings like bleeding time (BT) and clotting time (CT). "These are often insufficient to rule out haemophilia or related disorders. In fact, these tests can appear normal even in individuals with mild to moderate disease," says Dr Ramanan. For a definitive answer, women should request:1. Specific factor assays: (Factor VIII and Factor IX levels).2. von Willebrand Factor (vWF) testing.3. Comprehensive coagulation profiles: Including PT/INR and aPTT. The language of advocacy To break through medical scepticism, experts suggest that women use precise, clinical terminology when speaking to their doctors. "In describing their symptoms, women need to use precise terminology. Saying 'excessive menstrual bleeding' rather than 'excessive periods,' and terms like 'mucosal bleeding,' 'easy bruising,' and 'tendency to bleed' may encourage further investigation. Talking about disorders like haemophilia and von Willebrand disease might be useful as well,” advises Lahane. Dr Ramanan agrees, “Explicitly asking for a coagulation workup including factor assays signals to the doctor that the patient is informed and requires more than a cursory glance at her symptoms.” The safe list: Medications to avoid For a woman with a suspected or confirmed bleeding tendency, the medicine cabinet can be a minefield. Many common over-the-counter (OTC) painkillers can inhibit platelet function, making bleeding significantly worse. "Pain relievers such as Aspirin and Ibuprofen (NSAIDs) could contribute to further blood loss through their effects on platelets," warns Dr Lahane. He lists a few safe alternatives:1. Paracetamol: Generally safe for pain relief and fever.2. Tranexamic acid: A medication that can be prescribed by a haematologist to actively reduce heavy bleeding.3. Hormonal therapies: Useful for managing periods, but only under the combined supervision of a gynaecologist and haematologist. The path forward: Family screening Finally, the experts stress that diagnosis should be a family affair. If a male relative is diagnosed with haemophilia, the ripple effect screening must begin. "It is essential to evaluate female relatives—mothers, sisters, and daughters—even if they do not currently exhibit symptoms. Early identification allows for better planning during surgeries, childbirth, or other medical interventions, ensuring that appropriate precautions are in place," says Ramanan. World Haemophilia Day serves as a reminder that healthcare must be equitable. By moving beyond the carrier label and recognising the symptomatic woman, the medical community can finally provide these forgotten patients with the life-saving care they have always deserved.
17 April,2026 10:06 PM IST | Mumbai | Maitrai AgarwalHepatitis A is a mild viral infection, especially in children, who often go unnoticed or recover without major complications. However, doctors warn that the impact of Hepatitis A can be very different in adults, particularly those with underlying liver conditions such as fatty liver or cirrhosis. In such individuals, the infection can trigger severe complications, including acute liver failure, making early awareness, vaccination, and preventive care essential. Hepatitis A is a viral infection spread through contaminated food, water, or poor hygiene, causing symptoms like fever, fatigue, nausea, abdominal pain, and jaundice. Complications can include acute liver failure, prolonged jaundice, and in severe cases, life-threatening liver damage requiring hospitalisation or transplant. “Hepatitis A is less common in adults compared to children, but its severity depends largely on the existing health of the liver. Individuals with a healthy, non-fatty liver may experience only mild symptoms, similar to a routine viral illness, and recover without even realising they were infected. However, in patients with compromised liver health, the same infection can lead to serious outcomes. The condition can trigger acute liver failure or what doctors call acute-on-chronic liver failure in patients who already have liver damage. While younger patients with otherwise healthy livers may recover with proper medical management, those with early cirrhosis or advanced liver disease may not be able to regain normal liver function once it deteriorates. The ability of the liver to recover depends largely on its baseline health,” says Dr Anurag Shrimal, director – Liver Transplant at Gleneagles Hospital in Parel. Dr Shrimal further adds, “In many cases, younger patients without cirrhosis may recover well with timely treatment, even if complications arise. However, patients who already have early cirrhosis or significant liver damage may not be able to recover once their liver function declines. In such situations, liver transplantation becomes a critical, life-saving option. This highlights the importance of early diagnosis, timely medical intervention, and seeking care at specialised centres equipped to manage serious liver conditions. Prevention plays a key role in reducing the burden of Hepatitis A. Since it is a fecal-oral transmitted infection, maintaining good hygiene and sanitation can significantly reduce the risk. Vaccination is now available and is highly effective. Adults who are not already immune should consider taking the Hepatitis A vaccine, especially those with existing liver conditions. Protecting liver health through preventive measures can help avoid severe complications and improve overall outcomes.” Dr Rohan Chaudhary, associate director, HPB Surgery and Liver Transplant, at the hospital, explains, “Hepatitis A is often underestimated in adults, especially those who already have liver-related issues. What may appear like a simple infection can quickly worsen if the liver is not healthy. People need to understand the status of their liver health and report symptoms such as fatigue, jaundice, or loss of appetite to the expert for prompt intervention. Early medical care, along with preventive steps like vaccination and good hygiene, can go a long way in protecting the liver.” “We regularly see patients with advanced liver conditions, and our skilled team is well-equipped to manage complex cases, including liver transplants when required. We remain committed to strengthening liver care services and improving overall liver health through timely intervention and specialised treatment,” adds Dr Chaudhary. Dr Chetan Kalal, consultant Hepatologist and Transplant Physician at NewEra Hospital, Vashi, Navi Mumbai explains it more, saying, "Hepatitis A is usually considered a mild, self-limiting infection, and in most healthy individuals, recovery is complete. However, in clinical practice, we do see a different picture in patients who already have underlying liver disease." In individuals with fatty liver, Dr Kalal adds, advanced fibrosis, or cirrhosis, the liver’s reserve is reduced. When such a liver is exposed to an acute infection like hepatitis A, it may not be able to handle the additional stress. In some cases, this can lead to significant worsening of liver function and, rarely, acute liver failure or acute-on-chronic liver decompensation. "The concern today is that fatty liver is increasingly common and often undiagnosed, especially in younger individuals and those without obvious symptoms. This means a person may appear otherwise healthy but still be at risk if they acquire hepatitis A," Dr Kalal adds. At the same time, the city expert says it is important to clarify that hepatitis A does not cause chronic liver disease. The risk lies in how it interacts with a liver that is already compromised. From a preventive standpoint, safe food and water practices, good hygiene, and vaccination in at-risk individuals play an important role. "Early medical attention in patients with known liver disease who develop symptoms such as jaundice or vomiting is equally important," he concludes.
17 April,2026 09:20 PM IST | Mumbai | mid-day online correspondentAfter enduring the heartbreak of repeated second-trimester pregnancy losses and the uncertainty of a condition that made carrying a pregnancy extremely difficult, a 34-year-old Kolkata woman’s journey to motherhood found hope through a rare and high-risk surgical intervention by doctors in the 'City of Joy'. It began as a critically fragile pregnancy but was successfully carried to term, culminating in the birth of a healthy baby girl. Bidisha Majumder, a dietitian by profession and a resident of Garia, had a journey marked by repeated setbacks. Her first pregnancy in early 2024 ended in a miscarriage. Later that year, she conceived again, but at around 18–19 weeks in January 2025, she went into sudden preterm labour and lost the baby in an emergency. It was during this critical phase at that she came to Manipal Hospital EM Bypass and met Dr Souptik Gangopadhyay at the hospital. Subsequent evaluation revealed that she was suffering from cervical incompetence, a condition where the cervix is too weak to hold the pregnancy beyond a certain stage, leading to recurrent second-trimester losses. In her case, the condition was attributed to a congenital weakness of the cervical muscles. Determined to try again, the couple planned a third pregnancy, and she conceived around mid-2025. Given her history, she was closely monitored and underwent a prophylactic cervical cerclage (commonly known as McDonald’s stitch), which is a preventive medical procedure used during pregnancy to reduce the risk of miscarriage or preterm birth at around 13–14 weeks, this is a standard preventive procedure performed vaginally to help keep the cervix closed. Initially, the pregnancy progressed well. However, at around 20 weeks, a routine ultrasound revealed a critical complication, the cervical length had drastically reduced from a normal 3.5–4 cm to nearly 1 cm, and the amniotic sac (a thin, fluid-filled membrane inside the uterus that surrounds and protects the developing baby during pregnancy) had started bulging through the cervix, signalling an imminent risk of another pregnancy loss. With limited options available, the medical team recommended a laparoscopic rescue cervical cerclage, a rare and highly specialized procedure performed through minimally invasive surgery. Unlike the conventional stitch, this involves placing a suture higher up near the internal opening of the cervix through the abdomen, offering stronger support. The procedure is technically demanding and carries significant risks, including bleeding, need for transfusion, and complications due to surgery during an ongoing pregnancy. After extensive counselling, the couple chose to proceed with the surgery as a last resort. The procedure was successfully performed on December 19 in 2025. Following this, the patient was kept under strict observation, advised complete bed rest, and monitored through ultrasound every two weeks to ensure stability and foetal growth. As the pregnancy progressed safely, and with the baby reaching a healthy weight, the doctors planned a timely delivery to avoid any last-minute complications. On March 28 this year, they performed a planned caesarean section. The woman delivered a healthy baby girl weighing approximately 2.2 kg. Both mother and child are currently doing well. While discussing, Dr Souptik, consultant, Obstetrics & Gynaecology, said, “This was a complex case of recurrent second-trimester pregnancy loss due to cervical incompetence, where even a prophylactic cerclage failed as the cervix continued to shorten and dilate. In such situations, laparoscopic rescue cerclage becomes the only definitive option, despite being a technically demanding and high-risk procedure during an ongoing pregnancy. This is the first case in our hospital where this procedure has been performed, and it remains a rare intervention, with only a handful of such cases, around two–three reported across eastern India. After detailed counselling, the couple opted for the surgery as a last resort. The procedure was successfully performed in mid-December, following which the patient was kept under strict observation, advised rest, and closely monitored through fortnightly ultrasounds to ensure stability and healthy foetal growth. As the pregnancy progressed without further complications and the baby attained a healthy weight, we planned a timely delivery. On March 28, a planned caesarean section was performed, and the patient delivered a healthy baby girl weighing approximately 2.2 kg. Both mother and child are currently doing well.” Sharing his experience, Ronit Das, a software engineer and the woman’s husband, said, “We had been trying for the past two-three years, and going through two losses was emotionally exhausting for us. When the same complication started happening again in the third pregnancy, it was extremely stressful. Dr Souptik explained everything very clearly and gave us the option of this rare surgery. It was a difficult decision, but we trusted the team and went ahead with it. Today, seeing both my wife and baby healthy feels like a dream come true.”
17 April,2026 12:47 PM IST | Kolkata | mid-day online correspondentA team of researchers said on Wednesday that an increasing number of fungi are becoming resistant to medication, posing serious risks for patients with weakened immune systems. Under the leadership of Paul Verweij, medical microbiologist and professor at Radboud University Medical Center (Radboudumc) in the Netherlands, 50 researchers from 16 organisations worked together, according to a paper published in Nature Medicine. They gathered global data and developed a five-step plan to better monitor and prevent the rise of resistant fungi. The five steps include awareness, surveillance, infection prevention and control, optimised use, and investments. Fungal resistance does not develop in hospitals but originates largely in the environment. Fungicides used to protect crops against fungal plant diseases closely resemble the antifungal drugs used in healthcare. “Long-term exposure in agriculture allows fungi to develop resistance to these agents. These resistant fungi then spread through the air. As a result, resistance emerging in agriculture can lead to less effective treatments for patients with severe fungal infections,” said researchers. The widespread use of antifungal compounds across different sectors highlights the need for an integrated, or “One Health”, approach. “We are facing a silent surge of drug-resistant fungi – from Candida auris in ICUs to azole-resistant Aspergillus in the community – that is already costing lives. Antifungal resistance must be integrated into the 2026 Global Action Plan on AMR, with concrete milestones and funding, or we risk repeating the mistakes made with antibacterial resistance,” said Professor Paul E. Verweij, consultant microbiologist at Radboudumc. Dual use of antifungal targets in medicine and agriculture is accelerating resistance from fields to ICUs. “Aligning agricultural authorizations with health risk assessments, while investing in new antifungals and affordable diagnostics, is a pragmatic One Health solution that protects both food security and patient care,” said Professor Michaela Lackner, microbiologist at Medical University of Innsbruck. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
17 April,2026 11:00 AM IST | New Delhi | IANSArtificial intelligence (AI) can identify early risk pattern among individuals at higher risk of melanoma, a new study showed on Wednesday. The study was based on registry data that is routinely collected on the whole of Sweden’s adult population. The analysed data included age, sex, diagnoses, use of medications and socioeconomic status. Of the 6,036,186 individuals included, 38,582 (0.64 per cent) developed melanoma during the five years of the study. “Our study shows that data which is already available within healthcare systems can be used to identify individuals at higher risk of melanoma,” said Martin Gillstedt, a doctoral student at the University of Gothenburg’s Sahlgrenska Academy. This is not a form of decision support that is currently available in routine healthcare, but our results give a clear signal that registry data can be used more strategically in the future, said Gillstedt, a statistician at Sahlgrenska University Hospital’s Department of Dermatology and Venereology. When the researchers compared different AI models, the differences became clear. The most advanced model was able to distinguish individuals who subsequently developed melanoma from those who did not in about 73 per cent of cases, compared with about 64 per cent when only age and sex were used. The combination of diagnoses, medication and sociodemographic data made it possible to identify small, high-risk groups for whom the risk of developing melanoma within five years was around 33 per cent. “Our analyses suggest that selective screening of small, high-risk groups could lead to both more accurate monitoring and more efficient use of healthcare resources. This would involve bringing population data into precision medicine and supplementing clinical assessments,” said Sam Polesie, Associate Professor of Dermatology and Venereology at the University of Gothenburg. More research and policy decisions are needed before the method can be introduced in healthcare. However, the results show that AI models trained on large amounts of registry data can become an important source of support for more personalised risk assessments and future screening strategies for melanoma. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
17 April,2026 10:09 AM IST | New Delhi | IANSAs Mumbai experiences rising temperatures this summer, the Indian Meteorological Department (IMD) has also issued a yellow alert for Mumbai, Thane, Palghar and parts of Maharashtra on April 15. They have also predicted hot weather and heatwave conditions in parts of state including Sangli, Solapur and Akola. While heatwaves are now becoming a regular phenomenon due to rising global temperatures, Mumbai, which has become a concrete jungle, is also facing the wrath of the heat, which can affect a lot of people in different ways. It is also why people need to stay safe especially when they are stepping out during the summer season.A poster issued by the Ministry of Health and Family Welfare in the same post explains the phenomenon and how it affects the body and the need for heatstroke management. It says, "Rise in 1 degrees Celsius of global warming results in longer duration of heat waves." The advisory further adds that insufficient hydration during heat wave impairs body's innate ability to cool during high temperatures, resulting in a heat stroke. Here are five easy tips to avoid a heat stroke 1. Avoid heavy work during mid-noon2. Drink lots of water 3. Avoid drinking heavily caffeinated or sugary drinks which may cause dehydration 4. Wear light coloured clothes5. Take frequent rests between work when outside Here are four easy first aid tips for heat stroke 1. Place the person in a cool area lying down 2. Provide cold compression3. Give short sips of chilled water 4. After the person copes up, give foods high in moisture.While these health tips may seem easy, one may often ignore them, or take the heatwave for granted. However, it is important to follow them. Important facts to know about heatwaves What is a heatwave? The IMD highlights that Heat Waves are a period of unusually high temperatures as compared to what is normally expected over a region. While the temperature to declare a heatwave may depend from region to region, it says the impact of heat waves get aggravated by supportive meteorological factors such as high humidity, high wind speed, duration of heat wave events.Who is most vulnerable? While heatwaves affect people of all ages, elderly, children, sick or overweight as they are more likely to become victims of excessive heat, and it is important for them to take care during this time. More importantly, people who also work outdoors a lot, and are constantly travelling should take special care.What are the symptoms?Some of the early signs include exhaustion, heatstroke, fainting, fatigue, weakness and dizziness.What are the precautions that can be taken? Some of the precautions that can be taken include staying indoors and remaining cool at all times. If you feel dizzy or ill, it is important to visit the doctor.
16 April,2026 02:20 PM IST | Mumbai | mid-day online correspondentBread and other carbohydrate staples may be doing more than just filling plates--they could be quietly reshaping metabolism. In a surprising twist, researchers found that mice strongly preferred carbs like bread, rice, and wheat, abandoning their regular diet entirely. Even without eating more calories, they gained weight and body fat, not because they overate, but because their bodies burned less energy. Bread has long been a dietary cornerstone, sustaining societies for generations. It is deeply woven into everyday life. But with obesity rates continuing to climb, researchers are beginning to question whether this reliance on staple carbohydrates still makes sense in modern diets. Obesity increases the risk of many lifestyle-related diseases, making prevention a major public health priority. Traditionally, research has focused on high fat consumption as the main driver of weight gain. This is why many animal studies rely on high fat diets. However, carbohydrates such as bread, rice, and noodles are consumed daily around the world, yet their role in obesity and metabolism has not been explored as thoroughly. While many people believe that "bread makes you gain weight" or that "carbohydrates should be limited," it has been unclear whether the issue lies in the foods themselves or in how people choose and consume them. Study Explores Carb Preference and Metabolic Effects To better understand these questions, a research team led by Professor Shigenobu Matsumura at Osaka Metropolitan University's Graduate School of Human Life and Ecology studied how carbohydrates influence eating behavior and metabolism in mice. The researchers examined whether mice preferred foods like wheat, bread, and rice over standard chow, and how these choices affected body weight and energy use. The animals were divided into several feeding groups, including Chow, Chow + Bread, Chow + Wheat flour, Chow + Rice flour, High-fat diet (HFD) + Chow, and HFD + Wheat flour. The team tracked changes in body weight, energy expenditure, blood metabolites, and liver gene expression. Carb Preference Linked to Weight Gain Without More Calories The findings showed that mice strongly favoured carbohydrate-rich foods and stopped eating their standard chow altogether. Even though their total calorie intake did not increase significantly, both body weight and fat mass went up. Mice that consumed rice flour gained weight in a similar way to those that ate wheat flour. In contrast, mice given a High-fat diet (HFD) + Wheat flour gained less weight than those on a High-fat diet (HFD) + Chow. "These findings suggest that weight gain may not be due to wheat-specific effects, but rather to a strong preference for carbohydrates and the associated metabolic changes," said Professor Matsumura. Slower Energy Use May Drive Weight Gain The team also used indirect calorimetry with respiratory gas analysis to better understand energy use. The results showed that weight gain was not caused by "overeating," but by a reduction in energy expenditure. Further analysis revealed higher levels of fatty acids in the blood and lower levels of essential amino acids. In the liver, fat accumulation increased, along with the activity of genes linked to fatty acid production and lipid transport. When wheat flour was removed from the diet, both body weight and metabolic abnormalities improved quickly. This suggests that moving away from a wheat-heavy diet and toward a more balanced one may help regulate body weight more effectively. Next Steps: Applying Findings to Human Diets "Going forward, we plan to shift our research focus to humans to verify the extent to which the metabolic changes identified in this study apply to actual dietary habits," stated Professor Matsumura. "We also intend to investigate how factors such as whole grains, unrefined grains, and foods rich in dietary fiber, as well as their combinations with proteins and fats, food processing methods, and timing of consumption, affect metabolic responses to carbohydrate intake. In the future, we hope this will serve as a scientific foundation for achieving a balance between "taste" and "health" in the fields of nutritional guidance, food education, and food development," added Matsumura. The findings were published in Molecular Nutrition & Food Research. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
15 April,2026 09:31 AM IST | Washington DC | ANIArtificial Intelligence (AI) will play a pivotal role in accelerating drug discovery, enabling precision medicine and shaping a smarter, innovation-led healthcare ecosystem, according to experts. Pharma leaders emphasised reimagining processes rather than merely digitising existing systems. They highlighted the growing importance of strong data and technology foundations to enable scalable AI adoption and stressed the immediate benefits of automation in improving clinical efficiency. The first day of the 9th ‘India Pharma 2026’ witnessed four high-impact plenary sessions that brought together policymakers, industry leaders, regulators and technology experts to chart the future of India’s pharmaceutical and life sciences ecosystem. The inaugural plenary session highlighted the urgent need to bridge the gap between policy intent and on-ground execution. Manoj Joshi, Secretary, Department of Pharmaceuticals, emphasised industry-led model for Research and Development, importance of strengthening government lab networks and attuning regulatory model to that of European systems. Rajiv Bahl, Secretary, Department of Health Research, said though research funding has increased manifold over the last few years, the country needs a Bharat model of R&D with confidence of the market in the innovators and increased trust between industry and academia. According to the Ministry of Chemicals and Fertilisers, industry leaders echoed the need for increased venture capital participation and co-funding mechanisms to nurture research-driven enterprises, stronger industry-academia integration and underscored the importance of integrated ecosystems to translate early-stage discoveries into global solutions. The second plenary session focused on creating a predictable, efficient and globally aligned regulatory framework. Dr. Rajeev Singh Raghuvanshi, Drug Controller General of India, highlighted the importance of stakeholder consultations in shaping responsive regulatory systems. The third plenary session explored the transformative potential of artificial intelligence across the pharmaceutical value chain. The fourth session brought focus to India’s growing role in the global Contract Research, Development and Manufacturing Organisation (CRDMO) landscape. The panel noted that India’s CRDMO industry, currently valued at around $8 billion, has been growing at a robust pace of 10–12 per cent, reflecting strong global outsourcing demand. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
14 April,2026 11:28 AM IST | New Delhi | IANSTalegaon doctors have given a 63-year-old man battling advanced lung cancer a new lease of life with timely treatment. Struggling with severe breathlessness, constant cough, and swelling over the body, his condition had progressed to a stage where even basic daily activities became difficult. The doctors used advanced radiation therapy to help alleviate his symptoms and improve his overall condition, highlighting the impact of precision-based cancer care in critical cases. The patient, who is a resident of Talegaon, had been silently battling worsening breathlessness, a persistent cough, puffiness of the face, and swelling across his body for three weeks. At his age, even simple daily activities became exhausting, and his condition gradually took a toll on his strength and independence. His symptoms worsened and began to severely affect his quality of life. The patient went to various physicians and nearby hospitals, but none were able to relieve his symptoms. However, he approached TGH Onco Life Cancer Centre for treatment. Dr. Abhishek Purkayastha, consultant radiation oncologist at the hospital said, "The patient came to us in a critical state with severe breathlessness, persistent cough, and visible swelling of the face and whole body, all of which are signs of advanced lung cancer. He underwent a CT scan of the chest, which revealed a large mass in the upper lobe of the right lung measuring 10.4 x 9.3 x 8.5 cm. The tumour had spread to the right upper lobe bronchus, nearby airway structures, and the superior vena cava, causing significant compression and leading to his distressing symptoms. A biopsy confirmed the diagnosis of poorly differentiated adenocarcinoma. Considering the advanced stage of the disease and the patient’s fragile condition, a decision was made to initiate radiation therapy to provide symptomatic relief and control disease progression. The patient required urgent medical attention, as any delay in treatment could have led to serious, life-threatening complications. Locally advanced lung cancers can lead to airway blockage, reduced oxygen levels, and compression of major blood vessels, affecting the patient’s quality of life. Early diagnosis and timely medical intervention play a very important role in managing these cases and preventing further complications.” Dr Purkayastha further added, “The patient was treated using Volumetric Modulated Arc Therapy (VMAT), delivering 40 Gray radiation in 16 fractions. This advanced technique allows us to deliver highly precise radiation to the tumour through 360-degree rotating arc method while protecting surrounding vital organs such as the heart, lungs, and major blood vessels. The patient showed a very good response to the treatment, with complete relief from breathlessness, cough, and swelling. He required 16 sessions, and follow-up scans showed a reduction in the size of the tumor. Such advanced radiation technologies have made it possible to manage even complex and advanced cancers more effectively, improving survival for patients.” “I was constantly struggling to breathe, and even simple activities felt exhausting. After the treatment, my body swelling has reduced, I feel much better, and can breathe comfortably again. I am truly grateful to Dr Abhishek Purkayastha and his team for their timely care and support,” concluded the patient.
14 April,2026 10:59 AM IST | Talegaon | mid-day online correspondentFor years, a 31-year-old teacher silently endured severe pain during her periods, believing it was simply a normal part of being a woman. The pain was so severe at times that she often relied on painkillers and occasionally struggled to maintain her routine at work. When she and her husband finally began planning for a baby, the dream of motherhood suddenly seemed distant after doctors diagnosed her with severe endometriosis and low ovarian reserve (AMH), conditions that often make natural conception difficult. However, in a remarkable turn of events, timely laparoscopic surgery and specialised treatment has helped her conceive naturally and later welcome a healthy baby girl, 3.1kg kgs through a planned C-section, transforming years of pain and uncertainty into a story of hope. A silent struggle ignored for years The 31-year-old resident from Kharghar and a teacher by profession, was leading a happy and active life until persistent health issues began affecting her routine. For nearly two years, she had been experiencing severe pelvic pain during her menstrual cycles but assumed it was normal menstrual discomfort, something many women tend to ignore. After four years of marriage, when she and her husband began planning for a child, she noticed that she was not ovulating regularly. Concerned, she sought medical advice and underwent fertility evaluations. During her consultation in early 2025, Dr Surabhi Siddhartha, consultant, obstetrician and gynaecologist at Motherhood Hospitals in Navi Mumbai's Kharghar, advised detailed diagnostic tests, including Transvaginal Sonography (TVS), and a Color Doppler scan. The investigations revealed the underlying cause, which is endometriotic cysts and multiple endometriotic spots, confirming advanced endometriosis. The scans also showed dense pelvic adhesions, which were a major concern, where several organs, including the uterus, ovaries, and bladder, had become abnormally stuck to surrounding tissues due to the disease. Diagnosis: Endometriosis and low AMH Further investigations revealed that the patient had low Anti-Müllerian Hormone (AMH) levels, indicating reduced ovarian reserve. Endometriosis can damage ovarian tissue and disrupt ovulation, making natural conception difficult. Considering the combination of severe adhesions and low AMH, the patient had earlier been advised that she might require IVF treatment to conceive. Complex laparoscopic surgery restores hope After carefully evaluating her condition, the medical team led by Dr. Surabhi Siddhartha and Dr. Ujjwal Mahajan decided to perform advanced laparoscopic surgery to remove the endometriotic cysts and release the adhesions affecting the pelvic organs. Dr. Surabhi said, “During the surgery, we discovered extensive adhesions where the uterus had become attached to the bladder in the front and the intestines behind. Endometriosis often causes organs in the pelvic region to stick together due to scar tissue. Using laparoscopic keyhole techniques, we carefully separated these organs and removed the endometriotic cysts. The surgery requires great precision because there is always a risk of injury to nearby organs such as the bladder or intestines. At one stage, the team must meticulously separate the uterus from the bladder and intestines, which requires extreme precision to avoid injury to these delicate organs. The main goal was to restore the normal anatomy of the pelvic organs so that the chances of natural conception could improve. The surgery lasted for almost two hours.” She further explained that laparoscopic surgery offers several advantages, including smaller incisions, better visualization during surgery, minimal blood loss, faster recovery, and lower postoperative complications. Following the surgery, the patient was started on three cycles of hormonal injections (Leuprolide) to suppress any remaining endometriotic tissue and improve recovery. An unexpected but beautiful surprise To the delight of both the patient and the medical team, during the third to fourth month after surgery, the patient missed her period, and a pregnancy test confirmed that she had conceived naturally. Dr Surabhi further said, “This was a very special moment for both the patient and the medical team. Considering her low AMH levels and the severity of endometriosis, natural conception was uncertain. However, with timely surgery, hormonal support, and careful monitoring, she was able to conceive. Throughout the pregnancy, she was closely monitored with frequent antenatal visits and additional hormonal support to ensure the safety of both mother and baby.” A joyful beginning for the family Considering the dense pelvic adhesions observed during the surgery, a Caesarean section was planned to ensure a safe delivery. The patient successfully delivered a healthy baby girl, 3.1kg, bringing immense joy to the couple who had been trying to conceive for several years. “It felt like a miracle” Sharing her emotions after welcoming her baby, Aarti Sharma said, “For years I lived with severe period pain, thinking it was something every woman goes through. When we started planning for a baby after four years of marriage and were told about my condition, I felt scared and uncertain about whether I would ever become a mother. My husband stood by me through every difficult moment. When we were informed about the treatment and surgery, we decided to trust the process and stay hopeful. The day I found out that I was pregnant naturally, I simply could not believe it; it truly felt like a miracle. Today, holding my baby in my arms is the happiest moment of my life. I am deeply grateful to Dr. Surabhi and her team, who helped make our dream of becoming parents come true.” Endometriosis often goes undiagnosed “Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus. Over time, it can lead to cysts, severe pelvic pain, and dense adhesions between the uterus, ovaries, bladder, and intestines. Many women ignore severe menstrual pain, thinking it is normal. However, persistent or intense pelvic pain can be an important warning sign. Early diagnosis and timely treatment can significantly improve fertility outcomes and prevent complications. Women who experience severe menstrual pain, irregular ovulation, or difficulty conceiving should seek medical evaluation early," said Dr. Surabhi. Endometriosis affects millions of women worldwide and can lead to symptoms such as severe period pain, pelvic discomfort, irregular cycles, painful intercourse, and infertility. However, with early diagnosis, expert treatment, and timely medical care, many women can still achieve successful pregnancies.
13 April,2026 04:49 PM IST | Mumbai | mid-day online correspondentA woman in her 60s who was suffering from progressive Parkinson’s Disease for several years has shown significant improvement after advanced brain surgery. Mumbai doctors gave her hope after conducting a Deep Brain Stimulation (DBS) surgery. It was by Dr Manish Baldia at Wockhardt Hospitals in Mumbai Central, following initial diagnosis and treatment by Dr Prashant Makhija, consultant neurologist. The patient initially presented with gradual slowing of movements, difficulty in walking, reduced speech clarity, and tremors in her limbs. Like many patients, she initially attributed these symptoms to ageing and consulted multiple physicians before being evaluated for a neurological condition. Upon consultation with Dr Makhija, she was diagnosed with Parkinson’s disease and started on medication, which led to noticeable improvement in her symptoms. She continued treatment and regular follow-ups over the years. However, as the disease progressed, her dependence on medication increased, leading to higher doses and associated side effects — a common challenge seen in long-term management of Parkinson’s Disease. “At advanced stages, patients often experience fluctuations in response to medication and may develop side effects. This is when we consider advanced therapies such as Deep Brain Stimulation,” explained Dr Makhija. She was counselled about Deep Brain Stimulation (DBS), a procedure that helps regulate abnormal brain signals responsible for movement-related symptoms. After careful consideration and detailed discussions, she was referred for surgical evaluation. Following assessment, the patient underwent Deep Brain Stimulation (DBS) surgery by Dr Baldia, during which electrodes were implanted in targeted areas of the brain and connected to a programmable device that delivers controlled electrical stimulation. “The objective of DBS is to improve symptom control while reducing the need for high-dose medications, thereby enhancing the patient’s overall quality of life,” said Dr Baldia. Post-surgery, the device was carefully programmed and fine-tuned to achieve optimal results. The patient showed marked improvement in her symptoms, with better movement control and a significant reduction in medication requirement. She is now able to carry out her daily activities with greater ease and independence. With Parkinson’s disease being a progressive neurological disorder, experts highlight that while medications remain the first line of treatment, advanced options like DBS can offer substantial benefit in selected patients when symptoms become difficult to manage.
10 April,2026 02:31 PM IST | Mumbai | mid-day online correspondentADVERTISEMENT
