Scientists in Australia have mapped the "neighbourhoods" of lung cancer cells and found that cell metabolism plays a key role in determining how patients respond to immunotherapy. Researchers from the University of Queensland's (UQ) Frazer Institute studied cell interactions at cellular resolution in non-small cell lung carcinoma, the most common form of lung cancer, to better understand why some patients don't respond to immunotherapy treatment, Xinhua news agency reported. Using machine-learning algorithms and computational approaches, the team examined how cells interact and metabolise glucose, which cancer cells thrive on, said Associate Professor Arutha Kulasinghe from UQ's Frazer Institute. "We were able to dive deep into the complex nature of cells, basically looking at the cells' personal lives in the complex composition of a tumour, and found certain metabolic neighbourhoods were associated with response and resistance to immunotherapy," Kulasinghe said. Immunotherapy is costly and benefits only a minority of patients, he said. The researchers added that "it's important to understand how to identify these patients, and those that might need combination or alternative therapies." Lead author James Monkman from UQ's Frazer Institute said higher glucose uptake in cancer cells was associated with poorer outcomes. "We know cancer cells love sugar, and we analysed where glucose was being processed in the cells and where it wasn't," Monkman said. "You could have a region of a tumour processing glucose in a completely different way to another area of the tumour." The findings are published in the journal Nature Communications. The next step is to develop targeted treatments, such as with metabolic inhibitors, to make immunotherapy more effective, and eventually enable precision medicine tailored to each patient's tumour, with plans to extend the approach to other cancers, the researchers said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
04 February,2026 03:18 PM IST | New Delhi | IANSUp to four in 10 or 7.1 million cancer cases worldwide could be prevented, according to a new global analysis from the World Health Organization (WHO) and its International Agency for Research on Cancer (IARC) on Wednesday. The study, released on World Cancer Day on February 4, identified tobacco as the leading preventable cause of cancer globally, responsible for 15 per cent of all new cancer cases. It also found, for the first time, that nine cancer-causing infections are responsible for about 10 per cent of cancer cases. Other reasons include alcohol, high body mass index, physical inactivity, air pollution, and ultraviolet radiation. The analysis, based on data from 185 countries and 36 cancer types, estimated that 37 per cent of all new cancer cases in 2022, around 7.1 million cases, were linked to preventable causes. Three cancer types - lung, stomach and cervical cancer- accounted for nearly half of all preventable cancer cases in both men and women, globally. Lung cancer was primarily linked to smoking and air pollution, stomach cancer was largely attributable to Helicobacter pylori infection, and cervical cancer was overwhelmingly caused by human papillomavirus (HPV). "This is the first global analysis to show how much cancer risk comes from causes we can prevent," said Dr Ilbawi, WHO Team Lead for Cancer Control, and author of the study. "By examining patterns across countries and population groups, we can provide governments and individuals with more specific information to help prevent many cancer cases before they start," he added. The burden of preventable cancer was substantially higher in men than in women, with 45 per cent of new cancer cases in men compared with 30 per cent in women. In men, smoking accounted for an estimated 23 per cent of all new cancer cases, followed by infections at 9 per cent and alcohol at 4 per cent. Among women globally, infections accounted for 11 per cent of all new cancer cases, followed by smoking at 6 per cent and high body mass index at 3 per cent, the report said. The findings underscore the need for context-specific prevention strategies that include strong tobacco control measures, alcohol regulation, vaccination against cancer-causing infections such as human papillomavirus (HPV) and hepatitis B, improved air quality, safer workplaces, and healthier food and physical activity environments. Addressing preventable risk factors not only reduces cancer incidence but also lowers long-term health care costs and improves population health and well-being, the study said.
04 February,2026 03:00 PM IST | New Delhi | IANSHighlighting the growing financial strain in cancer care across India, a new analysis claims data reveal that cancer treatment is prolonged and costs a significant amount that can push patients and families. Every year, World Cancer Day 2026 is observed on February 4 to raise awareness about the disease that has adverse effects on human life, encouraging not only its prevention but also its detection and treatment. The claims analysis by Care Health Insurance shows that cancer treatment costs are rising sharply, with early-stage treatment typically costing Rs 5–7 lakh per case, while high-complexity and advanced cancers can push expenses to ₹20–30 lakh per treatment, depending on disease progression, care intensity, treatment protocol and period of treatment. This is particularly relevant in the context of the Union Budget 2026, which reinforces a renewed focus on affordable cancer care and reduced financial burden on patients. Commenting on the emerging trends, Manish Dodeja, who is the chief operating officer, Care Health Insurance, said, “Cancer treatment is not only medically complex but also involves prolonged and multi-stage care pathways, often extending over several months.” The findings show that cancer treatment journeys are long and multi-phased, often extending over several months. Patients typically file multiple claims across different stages of care. While chemotherapy and radiotherapy are largely covered as day-care procedures, hospitalisation requirements vary based on treatment complexity, with lengths of stay ranging from three days to as long as twenty days. The analysis also indicates that financial exposure may differ for different cancer types. Claims related to breast cancer, oral cancer, cervical cancer, prostate cancer and blood cancers, along with advanced pancreatic and liver cancers and among others consistently record varying claim values and have incidences of coverage limit breaches where the sum insured was low, resulting in increased out-of-pocket expenses. Based on observed claims experience, health coverage adequacy is emerging as a critical gap, with the analysis indicating that a minimum sum insured of Rs 15-25 lakh is increasingly required to adequately cover comprehensive cancer treatment, particularly in cases involving advanced-stage disease or prolonged care pathways. Moreover, having comprehensive coverage plays a key role in reducing financial stress during cancer treatment. Higher sum insured, no-claim bonus benefits, absence of sub-limits, access to a comprehensive, cashless healthcare provider network, and critical illness specific covers significantly help in lowering out-of-pocket expenses and supporting continuity of care. Manish further added, “This sustained and multi-stage care often translates into prolonged financial pressure for patients and their families. As treatment approaches evolve, and become more accessible over time, it is important for consumers to periodically reassess their health insurance coverage to ensure it provides adequate financial security through the course of care."
04 February,2026 02:52 PM IST | Mumbai | mid-day online correspondentTamil Nadu has crossed a critical public health threshold, registering more than one lakh new cancer cases in a single year for the first time. The latest figures for 2025, according to data submitted in Parliament by the Union Ministry of Health and Family Welfare, show 1,00,097 fresh cases in the state, underscoring a sharp and sustained rise in incidence and raising concerns among health authorities about prevention, early detection, and treatment capacity. Experts caution that without stronger screening programmes and lifestyle interventions, the numbers could continue to climb in the coming years. The upward trend has been consistent over the past five years. Annual registrations rose from 68,750 cases in 2020 to 76,968 in 2021; 89,265 in 2022; 92,816 in 2023, and 96,486 in 2024, before breaching the one-lakh mark this year. The steady escalation highlights the growing disease burden and the urgent need for coordinated public health measures across districts. Of the newly recorded cases in 2025, women accounted for 53,542 patients, while men comprised 46,555. The total number of people currently living with cancer in Tamil Nadu has reached 1,09,097, reflecting both increased incidence and improved survival that requires sustained medical support. Chennai continues to carry the heaviest caseload, reporting 8,505 new cases this year. Kancheepuram followed with 7,295 cases and Vellore with 6,525. Health professionals attribute higher numbers in urban areas to lifestyle-related risk factors, pollution exposure, stress, and delayed diagnosis. Cancer patterns also vary by gender. Among men, mouth cancer remains the most common, largely linked to tobacco consumption, followed by colorectal and stomach cancers. Among women, breast cancer leads, with cervical and ovarian cancers accounting for a significant share, indicating the need for stronger awareness and routine community screening initiatives. Medical experts note that nearly half of cancer cases are detected at advanced stages, reducing survival chances and increasing treatment costs. Preventive steps such as regular exercise, maintaining a healthy body weight, avoiding tobacco and alcohol, and undergoing periodic screenings are considered essential to lowering risk. Persistent lumps, unexplained weight loss, prolonged pain, or unusual symptoms require immediate medical attention. Meanwhile, data submitted in Parliament by the Health and Family Welfare Department revealed that 10,821 deaths in 2025 were linked to ovarian, breast, and cervical cancers alone. Public health specialists say the figures serve as a wake-up call for both policymakers and the public to prioritise awareness, screening, and early diagnosis to curb Tamil Nadu’s rising cancer burden. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
04 February,2026 11:30 AM IST | Chennai | IANSAmid a rapidly ageing population in India, experts on Tuesday, February 3, stressed the need for a home-based, community-led and integrated elder care model to boost geriatric care in the country. Speaking at an event held in the national capital, the health experts also discussed the growing challenges confronting the country’s elderly population and the urgent need for more responsive and inclusive approaches to geriatric care. The experts highlighted that the challenges for geriatric care are multi-dimensional in nature. These include rising disabilities and age-related health conditions such as dementia and Alzheimer’s, significant gaps in geriatric healthcare infrastructure coupled with a sharp urban–rural divide in access to medical services, and mounting economic pressures driven by inadequate social security and rising healthcare costs. “Ageing is not just about adding years to life, but adding life to those years. Geriatric care must be coordinated, continuous, community-based, and compassionate. Mental and emotional well-being are as critical as physical health, especially in an era of nuclear families and increasing social isolation. Geriatric care is not a luxury -- it is a necessity,” said Dr. Rajinder K. Dhamija, Director, Institute of Human Behaviour and Allied Sciences (IHBAS). According to government data, India's senior citizen population is projected to surge to around 230 million by 2036, making up about 15 per cent of the total population. “Geriatric care cannot remain confined to a few tertiary hospitals or centres of excellence. In a country as large and demographically diverse as India, care must begin at home and be strengthened through district-level systems. Many elderly health needs do not require hospitalisation but can be effectively managed through trained caregivers, home-based services, and coordinated community support. The real challenge is scale, integration, and last-mile delivery,” added Rajesh Bhushan, Former Secretary, Ministry of Health & Family Welfare, during the event organised by Illness to Wellness. Bhushan also highlighted the need to repurpose and upskill general physicians, integrate social care with medical services, and draw lessons from countries such as Japan and South Korea to create unified, one-stop elder care models that combine healthcare, rehabilitation, and social support. The experts also pointed to a widening digital divide, with many seniors struggling to adopt technology due to limited access and lack of age-friendly training, as well as physical infrastructure -- public spaces, transport systems, and emergency response mechanisms -- that remain largely ill-equipped to support the safety, mobility, and independence of older persons. Prof. Nirmal Kumar Ganguly, Former Director General, ICMR, noted that ageing outcomes are deeply influenced by social engagement, mental stimulation, and timely management of chronic conditions. “Age is truly just a number. Mental engagement, social interaction, and proactive management of vision, hearing, balance, and chronic diseases can dramatically improve quality of life. While challenges such as dementia, diabetes, and hypertension are rising, advances in technology and medical science offer real solutions -- provided they are made accessible and equitable,” he said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
03 February,2026 03:48 PM IST | New Delhi | IANSSlashing global aid, particularly by the US and European countries, will reverse decades of progress in fighting diseases, and lead to 22.6 million additional deaths in people of all age groups, including children under five years of age, by 2030, warned a new study published in The Lancet Global Health on Tuesday. The peer-reviewed study led by the Barcelona Institute for Global Health (ISGlobal), in Spain, showed that the additional deaths will be across 93 low- and middle- income countries, including India. The figures also include 5.4 million children under the age of five. Severe cuts to official development assistance (ODA) will affect Sub-Saharan Africa, accounting for 38 of the 93 countries analysed, the most. In Asia, 21 countries, including India, are at risk, followed by 12 countries each in Latin America, the Middle East, and North Africa. Ten countries in Europe, including Ukraine, will also be affected. “Withdrawing this support now would not only reverse hard-won progress but would translate directly into millions of preventable adult and child deaths in the coming years. Budget decisions made today in donor countries will have irreversible consequences for millions of people for years to come,” said Davide Rasella, Coordinator of the study, ICREA Research Professor at ISGlobal, and at the Brazilian Institute of Collective Health. The research also reveals that between 2002 and 2021, the ODA helped reduce global child mortality by 39 per cent; prevented HIV/AIDS deaths by 70 per cent, with a 56 per cent reduction in deaths from both malaria and nutritional deficiencies. It also increased additional global health outcomes in these 93 countries, which are home to 75 per cent of the world’s population. The international aid fell for the first time in six years in 2024. The US, UK, France, and Germany significantly reduced their ODA contributions for the first time in nearly 30 years. To understand the impact of the fund cuts, the study modelled two scenarios from 2025 through 2030. In case of a mild defunding scenario with a 10.6 per cent yearly reduction (corresponding to the average reduction of the last two years, 2024–2025), the cuts could result in 9.4 million preventable deaths, including 2.5 million children younger than five years. However, a severe defunding scenario, based on $32 billion (15.1 per cent) in ODA cuts from 2024 to 2025, could cause 5.4 million children younger than age five years to die as part of more than 22.6 million additional deaths of all ages. “These findings are a warning of the profound moral cost of the zero-sum approach many political leaders are taking -- and they are an urgent call to action to all of us to prevent this human suffering,” said Dr. Rajiv J. Shah, president of The Rockefeller Foundation, who supported the study. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
03 February,2026 12:04 PM IST | New Delhi | IANSMumbai doctors have successfully resolved a complex neurological case involving a 35-year-old nurse diagnosed with myasthenia gravis based on a positive antibody test and started on long-term medication. Expert reassessment and advanced neurophysiological testing overturned the diagnosis, safeguarding the patient from unnecessary immunosuppressive therapy. The patient from Navi Mumbai presented with drooping of her left eyelid (ptosis) that had persisted for several months. With a prior diagnosis of hyperthyroidism already complicating her plans for pregnancy, she initially consulted a neuro-ophthalmologist and later a neurologist at a healthcare facility in Mumbai. A blood test for acetylcholine receptor (AChR) antibodies returned positive, leading to a diagnosis of myasthenia gravis. She was started on steroids and pyridostigmine, medications that carry significant long-term implications, especially for young women. Already dealing with the emotional and physical burden of hyperthyroidism, the patient experienced growing anxiety after learning about myasthenia gravis and the possibility of lifelong immunosuppressive therapy. On the advice of a close friend, she sought a second opinion at Jaslok Hospital and Research Centre, where she consulted Dr Vinaya Bhandari, Consultant Neurology & Neuromuscular Disorder Specialist. At the hospital, a thorough re-evaluation was undertaken. An MRI of the brain ruled out a central nervous system cause for the eyelid drooping. Advanced nerve and muscle testing was then performed. Both repetitive nerve stimulation and, critically, single-fibre electromyography (SFEMG), the most sensitive diagnostic test for myasthenia gravis, were found to be completely normal. “Single-fiber EMG is the most sensitive test available for diagnosing myasthenia gravis, in patients presenting with isolated eye symptoms such as ptosis, double vision, difficulty swallowing, chewing, change in voice/speech, fatigue. A normal SFEMG in a clinically affected muscle makes myasthenia gravis extremely unlikely,” explained Dr Vinaya Bhandari, consultant Neurology & Neuromuscular Disorder Specialist, at the hospital. Based on these findings, myasthenia medications were discontinued. A detailed clinical history revealed that the patient had been frequently rubbing her left eyelid due to persistent itching. This led to a diagnosis of traumatic aponeurotic ptosis, a mechanical eyelid condition unrelated to nerve or muscle disease. The patient was reassured that while AChR antibodies are strongly associated with myasthenia gravis, false-positive results may occur, particularly in the presence of other autoimmune conditions such as thyroid disease. Antibody testing alone should not determine long-term treatment decisions. In situations where the clinical diagnosis is uncertain, electrophysiological confirmation with repetitive nerve stimulation and/or single-fibre EMG is recommended prior to initiating immunosuppressive therapy, to ensure diagnostic accuracy and avoid unnecessary exposure to treatment-related risks. Speaking about the case, Dr Bhandari, stated, “While a positive AChR antibody test supports the diagnosis of myasthenia gravis, it should not be interpreted in isolation. The diagnosis must be established through correlation with clinical features and objective neurophysiological evidence. In situations where the diagnosis is uncertain, electrophysiological testing such as repetitive nerve stimulation and particularly single-fibre EMG should be performed whenever feasible before initiating immunosuppressive therapy.” Adding to this, Dr Milind Khadke, chief medical officer with the hospital, emphasised, “This case reinforces the importance of evidence-based diagnosis and multidisciplinary evaluation.” The case serves as an important reminder for clinicians and patients alike: accurate diagnosis, supported by advanced neurophysiological testing, is essential before labelling a patient with a chronic neurological disorder and initiating lifelong treatment.
03 February,2026 10:16 AM IST | Mumbai | mid-day online correspondentAs the Union Budget 2026-27 approaches, the healthcare industry is looking towards the central government to bridge the gap between ambitious national goals and the ground realities of medical affordability. Dr P Senthilnathan, Director of GEM Hospital, emphasised that the roadmap for the upcoming year must be anchored in a long-term strategy. He noted that the previous budget made strides in making essential medicines more affordable and in advancing digital health initiatives, particularly by enhancing cancer care capacity nationwide. However, he believes the next step is critical for the nation's broader developmental goals. Dr. Senthilnathan stated, "Union Budget 2026-27 should be drafted keeping in mind the long-term vision for building "Healthy India" to achieve 'Viksit Bharat' by 2047." There is also a strong call for the government to lower or rationalise GST on essential medical tools and services. Dr Senthilnathan remarked, "lower or rationalise GST on medical devices, diagnostic kits, and health insurance premiums to manage high out-of-pocket expenses." By reducing these tax barriers, the industry hopes to see a direct drop in treatment costs and higher uptake of health insurance, which is currently underutilised due to high premiums. The focus on rural areas also remains a top priority. Dr Senthilnathan highlighted the importance of "focusing rural health infrastructure through the National Health Mission (NHM)." Beyond infrastructure, the industry is seeking stronger public-private collaborations to address the rising prevalence of chronic illnesses. Dr Senthilnathan proposed a more integrated approach, noting the need for "Government tie-up with private organisations for screening programs, and reducing the burden of non-communicable diseases." He believes that such partnerships are essential for early detection and long-term management of lifestyle-related ailments that are increasingly affecting the workforce. Finally, the hospital director emphasised that the future of Indian healthcare lies in technology and smart taxation. He called for "AI/telemedicine adoption, and providing tax rationalisation for diagnostics and devices." This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
01 February,2026 09:42 AM IST | New Delhi | ANIWith stroke cases rising rapidly across India and delays in diagnosis often costing patients their lives or mobility, a Mumbai hospital has taken a unique step to bridge this critical gap. Keeping the importance of the “golden window” of 4.5 hours in mind, the hospital has launched an AI-based Hub-and-Spoke stroke care model, with diagnostic centres acting as spokes and Gleneagles Hospital in Parel functioning as the central hub. This initiative ensures that the moment a suspected stroke is detected on CT or MRI, the hospital’s stroke team is alerted instantly, allowing faster decisions, quicker transport, and timely treatment. AI-enabled stroke response network Under this model, Dr Nitin Dange heads the stroke response team, supported by Dr Shirish Hastak and Dr Pankaj Agarwal, Dr Kushal Bhatia, and Dr Mayur Gharat receives real-time AI notifications on their mobiles the moment a suspected stroke is detected at any connected diagnostic centre. Understanding stroke and the urgency of time A stroke occurs when blood supply to the brain is either blocked (ischemic stroke) or when a blood vessel ruptures, causing bleeding (hemorrhagic stroke). Common causes include high blood pressure, diabetes, smoking, high cholesterol, and heart disease. If not treated quickly, a stroke can lead to paralysis, speech loss, permanent disability, or even death. The biggest challenge in stroke care is time. Many patients lose precious hours after diagnosis due to a lack of awareness, delayed referrals, or being taken to centres without advanced stroke facilities. Recognising this gap, the city hospital conceptualised an AI-driven Hub-and-Spoke model to ensure that diagnosis immediately translates into action. Dr Nitin Dange, director - Interventional Neurologist and Neurosurgeon, Gleneagles Hospital Parel says, “Gleneagles Hospital has taken the initiative of launching an AI-based Hub-and-Spoke stroke model to address the growing burden of stroke cases and the delays we commonly see in treatment. For the past six months, we have installed this AI software at selected diagnostic centres offering CT scan and MRI services in Mumbai and Navi Mumbai areas such as Ghatkopar, Mulund, and Panvel (and which other areas). The moment a scan suggests a stroke, the software automatically identifies whether it is a bleeding stroke or a blockage stroke, estimates the time of onset, and sends instant alerts to our stroke team on their mobile phones. This allows us to act immediately. In cases of blockage stroke, if the patient is within the 4.5-hour golden window, we can even start thrombolysis on the way while shifting the patient to our hospital for advanced procedures like mechanical thrombectomy. Till now, we have treated 3-4 patients so far under this model, all have shown good recovery. With more awareness and more diagnostic centres joining this network, many more stroke patients can receive life-saving treatment on time.” “This Hub-and-Spoke model is not just about technology; it is about saving time, brain function, and lives. By connecting diagnostic centres directly with our stroke specialists, we are ensuring that no patient loses crucial minutes due to confusion or delays. Our vision is to expand this network and collaborate with more centres so that early diagnosis leads to immediate treatment. With the rising incidence of stroke, such integrated care models will play a vital role in improving outcomes and creating greater public awareness,” concludes Dr. Bipin Chevale, CEO of the hospital. Strengthening stroke care through the Hub-and-Spoke Model The AI-based Hub-and-Spoke stroke model offers advantages for both diagnostic centres and hospitals. Diagnostic centres benefit by becoming active participants in life-saving care, ensuring that stroke findings are immediately escalated to specialist teams rather than ending at diagnosis. For the Hospital, the model enables early clinical decision-making, faster patient transfers, better utilisation of the golden window, and improved treatment outcomes. By creating a seamless, technology-driven link between diagnosis and intervention, the model reduces delays, optimises resources, and sets a new standard for coordinated stroke care.
30 January,2026 01:48 PM IST | Mumbai | mid-day online correspondentFor decades, the conversation around brain health has been dominated by a single image: a piece of salmon or a bottle of fish oil. For vegetarians, vegans, or those participating in Veganuary, this has often felt like an exclusion from essential cognitive nutrition.However, as we enter a new era of nutritional science, the focus is shifting. Experts argue that the brain can thrive on plant-based sources—if you know the kitchen chemistry required to unlock them. This Veganuary, we look at strategically using walnuts, chia seeds, and flaxseeds to help you feed your brain effectively while adhering to a plant-based lifestyle. The cognitive engine: Why your brain craves omega-3s The human brain is nearly 60 per cent fat, making the quality of your dietary fat intake a direct reflection of your cognitive performance. As Dr Preeti Mohanty, dietician at Apollo Clinic, explains, “For years, omega-3s have been closely associated with fish, leaving many vegetarians wondering where that leaves them. The good news is that plant-based foods like walnuts, chia seeds, and flaxseeds do offer Omega-3s. They are not just a single nutrient but a family of fats that serve as the building blocks for brain cells.” Below, she details reasons why omega 3 is important for brain health: Mood and motivationIn terms of mood regulation, Omega-3s have a positive effect on the neurotransmitters that affect the mood and motivation, such as serotonin and dopamine. Adequate Omega-3 intake appears to be associated with less anxiety, a better mood, and less mental fatigue. These improvements lead to better concentration, more effective stress management, and clearer thinking during mentally challenging situations, including exam periods and busy workdays. The anti-inflammatory shieldIn addition to providing a number of important functions, Omega-3s provide an additional benefit through their anti-inflammatory effects. Chronic, low-grade inflammation in the brain has been linked to cognitive decline and mood problems. By decreasing inflammation and oxidative stress in the brain, Omega-3 fatty acids support long-term brain health and may help to slow the decline of cognitive function due to age.The conversion challenge: Understanding ALA, EPA, and DHA Walnuts, chia seeds and flaxseeds contain high amounts of ALA (Alpha Linolenic Acid), which is an Omega 3 fatty acid that comes from plants. “However, when it comes to brain function, Omega 3 fatty acids exist mainly in the form of EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid). ALA can be converted to both EPA and DHA by our bodies, however, this conversion process is not the most effective,” explains Dr Mohanty. The primary hurdle for vegetarians is that plant sources contain ALA (Alpha-Linolenic Acid), whereas the brain primarily uses EPA and DHA. Mohanty notes that the body must convert ALA into these active forms, but the process is inefficient. On average: 1. ALA to EPA: 5 per cent to 10 per cent conversion.2. ALA to DHA: Less than 1 per cent to 5 per cent conversion. Factors influencing conversion Not everyone converts these fats at the same rate. Factors include:• Gender: Women of childbearing age often convert ALA more efficiently due to the influence of estrogen.• Age and genetics: As we age, our enzymatic efficiency may decrease.• Dietary habits: What you eat alongside your seeds determines how much of that ‘brain fuel’ actually makes it to its destination. Unlocking the nutrients: Preparation is everything “You cannot simply eat a handful of seeds and expect results. The physical structure of these foods determines their bioavailability,” explains Dr Mohanty. She outlines the best way to consume essential seeds:The flaxseed ruleThe grinding of flaxseeds drastically increases the number of nutrients absorbed by the body. Because of the hardness of the outer shell of a flaxseed, it typically does not break down until after passing time through the entire digestive tract. Therefore, the body is not capable of absorbing all of the Omega-3 from a whole flaxseed. To access the ALA and lignans inside, you must use freshly ground flaxseed. It is important to remember that ground flaxseed is highly sensitive to light and heat. For maximum storage efficacy, ground flaxseeds should be stored in an air-tight container in the refrigerator to avoid the possibility of their oxidation.The chia seed strategyWhen chia seeds are soaked or mixed with liquid, they form a gel-like substance that aids the body in digesting them. Although soaking chia seeds in liquid before consuming them may improve the absorption of the nutrients contained within slightly, for the majority of people, soaking them is more than adequate in order to achieve maximum absorption of nutrients.Kitchen chemistry: Managing heat and oxidationOne of the most common mistakes in plant-based nutrition is killing the fats before they reach the plate. “Omega-3s are polyunsaturated, making them the most chemically fragile fats in your pantry,” says Dr Tehseen Siddiqui, chief dietitian at Saifee Hospital. The heat shield conceptShe elaborates on the ‘bread and muffin rule.’ While Omega-3s are fragile, they can survive baking at 180 degree Celsius f they are encased in a moist dough. The water content acts as a heat shield, protecting the nutrients.No fryingIt is not advisable to use flax or walnut oil for high-heat frying.No dark toastingIf you toast walnuts until they are dark brown, the oils have likely oxidised, turning a healthy fat into a pro-inflammatory one. Optimisation strategies: The synergy secret For you to benefit from your seeds fully, you need to take them along with foods that aid in their absorption or conversion. “To overcome the low conversion rate of ALA, you must use synergistic foods—ingredients that work together to enhance absorption,” says Dr Siddiqui. She details four ways to extract the most nutritional benefit from your diet: Antioxidant powerhouseCombine your walnuts with blueberries and dark chocolate to get their polyphenols to preserve the Omega-3 fatty acids from becoming oxidised in your body and reaching your brain cells intact. A touch of fatWhile seeds contain their natural fat, having them after adding a touch of monounsaturated fat from an avocado is helpful for absorption. The turmeric connectionSome research has now shown that complementing your body’s ability with curcumin, which can be found in turmeric, can help your body turn ALA from plants into DHA, which happens to be your brain’s favourite form of Omega-3s. The role of micronutrientsConversion requires specific cofactors, a diet rich in zinc, magnesium, vitamin B6, and iron (found in whole grains and pulses) provides the enzymes necessary for fatty acid metabolism. The blockers: What to remove from your diet Optimising your Omega-3 levels requires more than just high-quality intake, it requires the removal of biological blockers. “Even the best plant-based diet can be undermined by common dietary staples that compete for the same enzymatic pathways, effectively neutralising your efforts,” says Richa Anand, chief dietitian, Dr L H Hiranandani Hospital in Powai. The Omega-6 competition Refined vegetable oils—such as sunflower, soybean, and corn oil—are dense in Omega-6 fatty acids. Because Omega-6 and Omega-3 share the same enzymatic machinery for processing, a high intake of these oils creates a biological bottleneck. This effectively crowds out Omega-3s, preventing your body from converting them into usable brain fuel. Swap refined vegetable oils for extra virgin olive oil, mustard oil, or rice bran oil to clear the pathway for brain-healthy fats. The inflammation trap Highly processed foods loaded with trans fats and added sugars trigger systemic inflammation. This inflammatory state acts as a direct antagonist to Omega-3s, neutralising their neuroprotective benefits. Essentially, a high-sugar diet mops up the potential gains from your walnut and chia seed intake before they can reach your brain. Refined sugars Excess sugar triggers systemic inflammation, which acts as a direct biological antagonist to Omega-3s. This creates a physiological zero-sum game where the neuroprotective benefits of your healthy fats are effectively neutralized by the inflammatory damage of refined sugars. The daily prescription: how much is enough? Consistency is the golden rule. You don't need ‘bucketloads’ of seeds, you need a daily habit. Anand suggests the following daily targets: 1. 7 to 10 halves of walnuts that are raw or lightly baked.2. 1 to 2 tablespoons of chia seeds that have been soaked in liquid.3. 1 to 2 tablespoons of freshly ground flaxseeds.
30 January,2026 11:02 AM IST | Mumbai | Maitrai AgarwalUse of artificial intelligence in Sweden's national breast cancer screening programme has revealed that AI-supported mammography screening is more effective than standard mammography, according to full results from a 2023 trial published in The Lancet journal. AI-supported breast cancer screening identified more women with clinically relevant cancers without a higher rate of false positives, the results show. Researchers from Lund University and other institutes in Sweden, Norway, Denmark and the Netherlands, also found that women who underwent AI-supported screening were less likely to be diagnosed with more aggressive and advanced breast cancer in the following two years. In August 2023, interim results from the Mammography Screening with Artificial Intelligence (MASAI) showed that use of AI resulted in the detection of 20 per cent more cancers compared with standard screening. The team also found that screen-reading workload for radiologists reduced by 44 per cent. The full results now show that AI-supported mammography also reduces cancer diagnoses in the years following a breast cancer screening appointment by 12 per cent -- a key test of screening programme effectiveness, the researchers said. "Our study is the first randomised controlled trial investigating the use of AI in breast cancer screening and the largest to date looking at AI use in cancer screening in general," lead author Dr Kristina Lang, a breast radiologist and clinical researcher from Lund University, Sweden, said. She added, "AI-supported screening improves the early detection of clinically relevant breast cancers which led to fewer aggressive or advanced cancers diagnosed in between screenings." Between April 2021 and December 2022, over 1,05,900 women were randomly assigned to either AI-supported mammography screening or to standard double reading by radiologists without AI. The AI system was trained, validated, and tested with more than two lakh examinations from multiple institutions across more than ten countries. During the follow-up period of two years, 1.55 interval cancers per 1,000 women (82/53,043) were detected in the AI-supported mammography group, compared to 1.76 interval cancers per 1,000 women (93/52,872) in the standard double reading group -- a 12 per cent reduction in interval cancer diagnosis for the AI arm. An interval cancer is a malignancy detected between scheduled screening tests, after a prior negative result and before the next routine check-up. Further, 81 per cent of cancer cases (338/420) in the AI-supported mammography group were detected at screening, compared to 74 per cent of cancer cases (262/355) in the standard reading group -- a nine per cent increase. Rates of false positives were similar for both the groups -- 1.5 per cent in the AI-assisted mammography reading and 1.4 per cent in the standard reading group. "Widely rolling out AI-supported mammography in breast cancer screening programmes could help reduce workload pressures amongst radiologists, as well as helping to detect more cancers at an early stage, including those with aggressive subtypes," Lang said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
30 January,2026 09:47 AM IST | New Delhi | PTIADVERTISEMENT
