Subscription Subscription
Home > Lifestyle News > Health And Fitness News > Article > Variations in skin composition linked to causing psoriasis atopic dermatitis Study

Variations in skin composition linked to causing psoriasis, atopic dermatitis: Study

Updated on: 29 March,2023 05:54 PM IST  |  California

Research states that different skin characteristics at different body sites may affect the skin's susceptibility to certain diseases

Variations in skin composition linked to causing psoriasis, atopic dermatitis: Study

Image for representational purposes only. Photo Courtesy: iStock

About 84.5 million people suffer from skin conditions. There are many different skin conditions that can be caused by ageing, trauma, environmental causes, and genetics. According to two recent UC Davis Health research, psoriasis and atopic dermatitis may be caused by variations in skin composition. "Skin does not have a uniform composition throughout the body," said Emanual Maverakis, professor of dermatology, molecular medical microbiology at UC Davis and senior author on both studies. "Different skin characteristics at different body sites may affect the skin's susceptibility to certain diseases."

Body site determines skin structure and function and disease susceptibility

The skin is the largest organ in the body. It has an average area of about 20 square feet -- that's the size of a 4' by 5' room! Its outermost layer (epidermis) has a lipid matrix composed of free fatty acids, cholesterol and ceramides (a family of waxy lipid molecules).

This layer must meet the environmental challenges specific to each area of the body. For example, the skin of the face needs to be thin and flexible to accommodate facial expressions. The skin covering the heel of the foot has to be thick and rigid to withstand force and protect it from objects we step on.

Skin composition depends on multiple factors, including the structure of the skin barrier, the cell types, and the genes they express.

Until recently, little was known about the cellular and molecular processes behind these differences. In the first study, researchers showed the mechanisms that lead to these structural changes in the skin.

The epidermis has a "brick and mortar" structure: molecules like ceramides, cholesterol and fatty acids make up the "mortar," and cells called keratinocytes are the "bricks."

The researchers used single-cell sequencing to characterize how the keratinocytes differ at different body sites. They also used targeted molecular profiling to characterize the molecules that form the "mortar" between the keratinocytes. They then examined how these differences in gene expression matched the compositional differences in the lipid and protein structures across body sites. These experiments explained why the skin looks so different at different body sites.

The compositional differences in the skin's lipids and proteins across different body sites may also explain why different skin diseases are found at different body sites. While characterizing the specific lipid alterations associated with various skin diseases, the researchers discovered that lipids stuck to a piece of tape applied to the skin were sufficient to diagnose a patient with a particular skin disease.

"These discoveries will lead to non-diagnostic tests for common dermatologic disease" said co-lead author, Project Scientist Alexander Merleev.

"These differences are also relevant to the future design of skin care products," said Stephanie Le, dermatology resident and co-lead author of the study. "They demonstrate how skin care products should be specifically formulated to match the particular body site that they will be applied to."

Psoriasis and the immune system

In the second study, the research team studied how skin cells interact with the immune system.

Previously, it was known that keratinocytes could secrete substances that both increase and decrease inflammation. Using single-cell sequencing to analyze each keratinocyte individually, the researchers observed that these immune-modulating molecules were expressed in certain layers of the epidermis.

Keratinocytes at the lowest layer of the epidermis secrete immune-attracting and immune anti-inflammatory molecules. This is to attract immune cells to the skin and park them in place to wait patiently to fight off any pathogenic microbe or parasite that might break through the physical barrier of the skin. In contrast, they found that the keratinocytes in the outer layer of the epidermis secrete proinflammatory molecules, in particular IL-36.

IL-36 is a main mediator of a subtype of psoriasis, an inflammatory skin disease. The team found that the amount of IL-36 in the skin was regulated by another molecule called PCSK9 and that individuals with variations in their PCSK9 gene were predisposed to developing psoriasis.

"Our discovery that different layers of the skin secrete different immune mediators is an example of how the skin is highly specialized to interact with the immune system. Some people develop skin diseases, such as psoriasis, when there is an imbalance in the molecules secreted by the different layers of the skin." said UC Davis research fellow Antonio Ji-Xu, co-lead author of the study.

Also Read: Everything you need to know about freezing your eggs

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/ reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

"Exciting news! Mid-day is now on WhatsApp Channels Subscribe today by clicking the link and stay updated with the latest news!" Click here!

Register for FREE
to continue reading !

This is not a paywall.
However, your registration helps us understand your preferences better and enables us to provide insightful and credible journalism for all our readers.

Mid-Day Web Stories

Mid-Day Web Stories

This website uses cookie or similar technologies, to enhance your browsing experience and provide personalised recommendations. By continuing to use our website, you agree to our Privacy Policy and Cookie Policy. OK