The study, published in the journal Science Translational Medicine, found that using the two treatments together may work better than using either on its own
Image for representational purpose only. Photo Courtesy: File pic
A team of Australian researchers has tested a new way of treating childhood brain cancer by combining two medicines in lab studies.
The study, published in the journal Science Translational Medicine, found that using the two treatments together may work better than using either on its own.
The team from the Children's Cancer Institute and University of New South Wales, tested a combined therapy approach on a group of difficult-to-treat brain tumours: diffuse midline gliomas (DMG) in the lab.
This group includes diffuse intrinsic pontine glioma (DIPG) -- a rare but fatal childhood brain cancer and a type of DMG. Children diagnosed with DIPG usually survive for about 12 months.
"We recognise that no single drug treatment is able to eradicate the most aggressive of brain cancers on its own," said Conjoint Associate Professor Maria Tsoli, from UNSW.
She said this is what led the researchers to see if combining treatments could work better.
UNSW Conjoint Professor David Ziegler said one of the biggest challenges with these tumours is that thousands of genes are switched on at the same time, driving the cancer's growth.
"It has proven extremely difficult to find a way to switch them all off," he said.
The researchers said that DMG cells grow out of control because of changes that disrupt normal gene activity.
The study discovered a promising combination of drugs that successfully shuts down the transcription process, effectively switching off thousands of genes at once, they explained.
The team focused on two important proteins involved in transcription: FACT and BET -- found at high levels in cancer cells. Drugs that block these proteins already exist, but when used on their own, they only slow the cancer slightly.
But when used together, the cancer cells died in laboratory experiments.
Experiments in mice showed that it slowed tumour growth and helped the mice live longer.
The researchers also found the treatment activated signals linked to the immune system. This means the cancer cells may become easier for the body's immune system to recognise and target.
Because of this, the researchers think that adding an immune-based treatment, such as CAR T-cell therapy, could work even better in the future.
The researchers said both types of drugs are already being developed for use in patients, as they are now in clinical trials.
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